Fundació Institut De Recerca De L'hospital De La Santa Creu I Sant Pau

This study tests a drug called afatinib in 25 adults with Fanconi anemia who have advanced head and neck cancer that cannot be removed by surgery. Afatinib is a pill that blocks a protein helping cancer grow. The goal is to see if it can shrink tumors and control the disease. Res…

This study tests whether 3D-printed models and custom surgical guides can help surgeons better plan and perform wrist bone cuts for Kienbock's disease (stages II and III). About 20 adults will receive the 3D-assisted surgery, and researchers will measure pain, wrist function, and…

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This study looks at whether a lower daily dose of the heart medication amiodarone can keep the heart in a normal rhythm as well as the standard dose, but with fewer side effects. About 312 adults with persistent atrial fibrillation who have had a successful electrical shock to re…

This phase 2 trial tests whether nicotinamide (a form of vitamin B3) can stop or reverse liver fibrosis in people with non-alcoholic fatty liver disease and obesity. Thirty adults will take either nicotinamide or a placebo daily for one year. Researchers will measure liver stiffn…

This study tests if the drug levetiracetam can prevent epileptic seizures in 120 adults over 40 with Down syndrome and Alzheimer's disease. Participants will receive either the drug or a placebo for 96 weeks. The goal is to see if the drug can stop seizures and possibly slow brai…

This study tests whether combining a nasal spray (oxytocin) with a 5-week self-compassion training program can reduce symptoms like self-criticism, shame, and emotional instability in people with borderline personality disorder (BPD). About 80 adults with BPD will receive either …

This study compares two techniques used during lumbar fusion surgery to see which one better reduces bleeding and pain after the operation. About 62 adults having back fusion surgery will be randomly assigned to receive either a large-volume injection of numbing medicine with a v…

This study tests a 'fast-track' recovery plan for children aged 2 to 17 who had surgery for a burst appendix. The goal is to see if they can go home sooner without raising the risk of problems like infection or needing another surgery. About 772 children will take part, and their…

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. The goal is to prevent skin injuries, reduce discomfort, and lower the risk of catheter-related infections. About 188 adults in intensive care will be ra…

This study tests a new psychological program called 'Feeling Safe' for people with psychosis who have persistent delusions. The program offers personalized modules to improve sleep, reduce worry, boost self-confidence, lessen the impact of voices, and build a sense of safety. Res…

This study is testing whether a simpler surgery (Weil osteotomy) works as well as a more complex one (Weil osteotomy plus plantar plate repair) for people with floating toe. Floating toe is a condition where the toe does not touch the ground properly. The study will enroll 70 adu…

This observational study aims to see if frailty—a state of increased weakness and vulnerability—differs between men and women with MASLD (fatty liver disease). Researchers will track 140 participants over time using physical tests and questionnaires. No drugs or treatments are be…

This study tests a modified blood-thinning protocol using citrate during continuous kidney replacement therapy in 43 ICU patients with acute kidney injury. The goal is to see if the new method reduces loss of important minerals like potassium and magnesium, cutting down on the ne…

This study aims to identify different subgroups among people with type 1 diabetes by analyzing their health data using artificial intelligence. Researchers will look at clinical records and glucose monitoring information from 800 adults. Participants do not need to do anything ex…

This study explores whether machine learning can analyze breathing test results to predict chronic respiratory diseases like asthma and COPD. Researchers will compare a newer technique called oscillometry with standard spirometry in 50 adults. The goal is to see if this approach …

This study follows 1,260 women 3 to 6 years after their first pregnancy to see how pregnancy complications like preeclampsia affect heart health. Researchers will check blood pressure, heart function, and artery health, and also look at lifestyle and environment. The goal is to c…

The FIRST-CARE study is a research project in Barcelona that will follow 225 women who have had a miscarriage in the first 14 weeks of pregnancy. Researchers will look at genetic, hormonal, immune, and other factors to better understand why miscarriages happen. The goal is to imp…

This study looks at why people with damage to the hypothalamus or pituitary gland often have sleep problems. Researchers will compare 60 patients to healthy volunteers using sleep tests, hormone measurements, and brain scans. The goal is to find better ways to prevent and treat t…

This study interviews 25 people with MASH (a fatty liver disease linked to metabolism) to learn about their expectations, attitudes, and unmet needs before and after joining a special heart-liver program. Participants will have two private interviews. The goal is to improve care …

Researchers are developing and testing a new questionnaire to objectively measure how severe a person's chronic cough is. The study will enroll 100 adults, including both chronic cough patients and healthy volunteers. The goal is to create a reliable tool that doctors can use to …

This study aims to find out how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect swab samples from 384 men with Crohn's disease or ulcerative colitis and test for HPV and abnormal cell changes. The goal is t…

This study follows 48 adults with active Crohn's disease or ulcerative colitis who are starting biologic or JAK inhibitor therapy. Researchers use a quick, painless bioelectrical impedance scan to measure muscle mass and other body composition changes at the start, 24 weeks, and …