New study aims to decode rare bone disease without surgery

NCT ID NCT05284006

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for children with Morquio A, a rare genetic disease that affects bones and breathing. Researchers will use safe, non-invasive tests like MRI, X-rays, hearing tests, and walking analysis to track how the disease changes over time. The goal is to better understand the disease and find better ways to measure it in future treatment studies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to better ways to track Morquio A progression and define clear endpoints for future treatment trials.
What could go wrong
This is an observational study, not a treatment trial. It will not directly improve symptoms or cure the disease. Results may take years to influence clinical care.

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Conditions

The condition(s) this trial relates to.

Dwarfism Mucopolysaccharidosis IV mucopolysaccharidosis type 4A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Nemours Children's Health, Delaware Valley

    RECRUITING

    Wilmington, Delaware, 19803, United States

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