New shot aims to toughen fragile bones in rare disease
NCT ID NCT07557446
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effects and measures changes in bone density over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AGA2115 (a drug injected under the skin to strengthen bones)
What this could lead to
If successful, this could point toward a new treatment to improve bone density and reduce fractures in people with osteogenesis imperfecta.
What could go wrong
This is an early-phase trial with only 48 participants, so results may not apply to everyone. The drug may cause side effects or fail to improve bone strength significantly.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, Jiangsu, 215025, China
Contact
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Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100005, China
Contact
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Shanghai Sixth People's Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200233, China
Contact
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The University of Hong Kong-Shenzhen Hospital
RECRUITINGShenzhen, Guangdong, 518053, China
Contact