New shot aims to toughen fragile bones in rare disease
NCT ID NCT07557446
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests a drug called AGA2115 in 48 Chinese adults and adolescents with osteogenesis imperfecta (types I, III, IV), a condition that makes bones brittle. Participants receive one of three dose schedules by injection under the skin. The study checks for side effects and measures changes in bone density over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- AGA2115 (a drug injected under the skin to strengthen bones)
- What this could lead to
- If successful, this could point toward a new treatment to improve bone density and reduce fractures in people with osteogenesis imperfecta.
- What could go wrong
- This is an early-phase trial with only 48 participants, so results may not apply to everyone. The drug may cause side effects or fail to improve bone strength significantly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Soochow University
NOT_YET_RECRUITINGSuzhou, Jiangsu, 215025, China
-
Chinese Academy of Medical Sciences, Peking Union Medical College Hospital
RECRUITINGBeijing, Beijing Municipality, 100005, China
-
Shanghai Sixth People's Hospital
NOT_YET_RECRUITINGShanghai, Shanghai Municipality, 200233, China
-
The University of Hong Kong-Shenzhen Hospital
RECRUITINGShenzhen, Guangdong, 518053, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Gentle exercise with cuffs may strengthen bones and muscles in brittle bone disease
- New shot aims to fortify fragile bones in brittle bone disease trial
- Brittle bones, fragile hearts? new study investigates cardiac risks in OI
- New drug aims to slash fractures in brittle bone disease
- Brittle bone breakthrough? drug may restore hearing
- New drug aims to cut fractures in kids with brittle bones