Osteoporosis drug may also preserve muscle in the elderly
NCT ID NCT06118905
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether Denosumab, a drug used for osteoporosis, can help preserve muscle strength and mobility in frail adults aged 65 and older living in nursing homes or assisted living. Participants will receive either Denosumab or Zoledronic Acid, and researchers will measure changes in knee extension strength over time. The goal is to see if this medication can improve muscle health and function in a vulnerable population.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Denosumab (Prolia) and Zoledronic Acid (Reclast)
- What this could lead to
- If it works, this could show that an existing osteoporosis drug also helps maintain muscle strength and mobility in older adults, potentially reducing falls and frailty.
- What could go wrong
- This is a phase 4 trial with 155 participants, so results may not apply to everyone. The primary focus is on muscle strength, not fracture prevention, and benefits may be modest or not clinically significant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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St. Barnabas Woodlands
RECRUITINGPittsburgh, Pennsylvania, 16059, United States
Contact
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