New imaging technique could help surgeons spot hidden parathyroid tumors

NCT ID NCT07444723

Recruiting now Diagnosis Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new type of PET scan using a radioactive tracer called 18F-FCH can more accurately locate overactive parathyroid glands or tumors before surgery. About 193 adults scheduled for parathyroid removal will receive both the new scans and a standard 4D-CT scan for comparison. The goal is to see if the new imaging reduces false positives and helps surgeons find the right gland the first time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: 18F-Fluorocholine (a radioactive tracer)
What this could lead to: If successful, this could make it easier and more accurate for surgeons to find parathyroid tumors before surgery, potentially improving outcomes and reducing repeat surgeries.
What could go wrong: This is an early-phase study focused on imaging accuracy, not treatment. The new scans may not prove significantly better than current methods, and the radioactive tracer carries a small radiation risk.

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Conditions

The condition(s) this trial relates to.

familial primary hyperparathyroidism hereditary hyperparathyroidism hyperparathyroidism 2 with jaw tumors malignant tumor of parathyroid gland multiple endocrine neoplasia multiple endocrine neoplasia type 1 Parathyroid Neoplasms primary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HERITABLE HYPERPARATHYROIDISM HYPERPARATHYROID-JAW TUMOR SYNDROME MULTIPLE ENDOCRINE NEOPLASIAS PARATHYROID CANCER PRIMARY HYPERPARATHYROIDISM

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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