New imaging technique could help surgeons spot hidden parathyroid tumors

NCT ID NCT07444723

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a new type of PET scan using a radioactive tracer called 18F-FCH can more accurately locate overactive parathyroid glands or tumors before surgery. About 193 adults scheduled for parathyroid removal will receive both the new scans and a standard 4D-CT scan for comparison. The goal is to see if the new imaging reduces false positives and helps surgeons find the right gland the first time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

18F-Fluorocholine (a radioactive tracer)

What this could lead to

If successful, this could make it easier and more accurate for surgeons to find parathyroid tumors before surgery, potentially improving outcomes and reducing repeat surgeries.

What could go wrong

This is an early-phase study focused on imaging accuracy, not treatment. The new scans may not prove significantly better than current methods, and the radioactive tracer carries a small radiation risk.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

familial primary hyperparathyroidism hereditary hyperparathyroidism hyperparathyroidism 2 with jaw tumors malignant tumor of parathyroid gland multiple endocrine neoplasia multiple endocrine neoplasia type 1 Parathyroid Neoplasms primary hyperparathyroidism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••