Massive gene hunt launched for eye and nerve disorders

NCT ID NCT03059420

Recruiting now Knowledge-focused Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which could lead to improved diagnosis and future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could identify new genes involved in eye movement and cranial nerve disorders, potentially pointing toward future treatments or diagnostic tests.
What could go wrong: This is an observational study, not a treatment trial. It may take many years to yield useful results, and there is no guarantee that new genes will be found or that findings will lead to therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abducens Nerve Diseases abducens nerve palsy accessory nerve disorder Athabaskan brainstem dysgenesis Bell's palsy Brown syndrome Congenital Cranial Dysinnervation Disorders congenital fibrosis of extraocular muscles conjugate gaze palsy Duane retraction syndrome Duane-radial ray syndrome facial paralysis Facial paresis, hereditary, congenital fourth cranial nerve palsy Glossopharyngeal Nerve Diseases glossopharyngeal nerve disorder horizontal gaze palsy with progressive scoliosis human HOXA1 syndromes hypoglossal nerve disorder isolated hereditary congenital facial paralysis jaw-winking syndrome levator-medial rectus synkinesis Mobius syndrome ocular motility disease Ocular Motility Disorders strabismus Synkinesis third cranial nerve disorder trochlear nerve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATHABASKAN BRAINSTEM DYSGENESIS BROWN SYNDROME CONGENITAL FIBROSIS OF EXTRAOCULAR MUSCLES DUANE RADIAL RAY SYNDROME DUANE RETRACTION SYNDROME ELEVENTH NERVE DISORDER FACIAL PALSY FACIAL PARESIS, HEREDITARY, CONGENITAL FIFTH NERVE PALSY FOURTH NERVE PALSY HORIZONTAL GAZE PALSY HORIZONTAL GAZE PALSY WITH PROGRESSIVE SCOLIOSIS LEVATOR-MEDIAL RECTUS SYNKINESIS MARCUS GUNN SYNDROME MOBIUS SYNDROME MOEBIUS SEQUENCE NINTH NERVE DISORDER OCULAR MOTILITY DISORDERS SEVENTH NERVE PALSY SIXTH NERVE PALSY STRABISMUS CONGENITAL SYNKINESIS THIRD NERVE PALSY TONGUE PARALYSIS TWELFTH NERVE DISORDER VAGUS NERVE PARALYSIS

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States

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