Strabismus
MONDO:0003432Strabismus is the intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object as the other eye. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. Strabismus is normal in newborns but should resolve by the time the baby is 6 months old. In older children with strabismus, the brain may learn to ignore the input from one eye, and this may lead to amblyopia, a potentially permanent decrease in vision in that eye if not corrected.
Also known as: squint, strabismus
38 clinical trials for this condition and its sub-types.
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Broader categories
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Eye exercises at home may help control wandering eyes when looking far away
Disease control Recruiting nowThis trial tests a 12-week home-based eye training program for children and young adults aged 6 to 25 with intermittent exotropia, a condition where one eye periodically turns outward. The training uses a computer or tablet game with 3D glasses to strengthen near vision control, …
Phase: NA • Sponsor: The Hong Kong Polytechnic University • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Special videos may help kids with wandering eyes avoid surgery
Disease control Recruiting nowThis study tests whether watching custom dichoptic videos for 8 weeks can improve eye alignment control in children with intermittent exotropia (a type of eye misalignment). Forty children will be assigned to watch either dichoptic or standard videos. The goal is to see if this n…
Phase: NA • Sponsor: Retina Foundation of the Southwest • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Eye muscle transplant or Y-Split: which fixes severe crossed eyes better?
Disease control Recruiting nowThis study tests two surgical methods to correct large-angle exotropia (a type of crossed eyes) using only one eye. One method moves a piece of muscle to the side, the other splits the muscle in a Y-shape. Researchers will measure how straight the eyes become and check for any si…
Phase: NA • Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Eye exercises vs prisms: which works better for crossed eyes?
Disease control Recruiting nowThis study compares two treatments for a type of crossed eye (small-angle esotropia) that started recently. One group will do special eye exercises, and the other will wear prism glasses. The goal is to see which approach better straightens the eyes and improves 3D vision. About …
Phase: NA • Sponsor: Eye & ENT Hospital of Fudan University • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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New headset therapy may reduce need for repeat eye surgeries in kids
Disease control Recruiting nowThis study tests a non-surgical treatment for intermittent exotropia, a condition where one eye drifts outward. Children aged 4-7 will use a special headset for one hour daily, six days a week, for 12 weeks. The goal is to improve eye control and reduce the need for surgery.
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Nasal spray may reduce agitation in kids after eye surgery
Symptom relief Recruiting nowThis study tests whether a nasal spray of dexmedetomidine can reduce agitation in children aged 3-6 after strabismus (eye muscle) surgery. 120 children will receive either 2 or 3 micrograms per kilogram of the medicine. The goal is to find the best dose to help children wake up c…
Phase: NA • Sponsor: Alexandria University • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC
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VR eye workouts could help people with eye nerve damage move their eyes better
Symptom relief Recruiting nowThis study tests whether doing eye exercises in virtual reality can help people with certain eye nerve palsies move their eyes more. The VR scene moves with the person's head while they do visual tasks. The goal is to see if this improves eye movement range. The study involves 40…
Phase: NA • Sponsor: Kevin Houston • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Can a simple drug stop kids from waking up confused after eye surgery?
Symptom relief Recruiting nowThis study tests whether giving sugammadex (a drug that reverses muscle relaxants) can lower the chance of children waking up agitated after strabismus (eye muscle) surgery. About 76 children aged 4 to 7 will be randomly assigned to receive either sugammadex or a standard drug (n…
Phase: PHASE4 • Sponsor: Konkuk University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Video games could be the new treatment for lazy eye
Symptom relief Recruiting nowThis study is testing whether playing video games and doing special vision exercises can improve eyesight in both children and adults with amblyopia (lazy eye). Researchers will measure changes in visual acuity, depth perception, and contrast sensitivity before and after the trai…
Phase: NA • Sponsor: Nova Southeastern University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Rural Kids' vision at risk: new program aims to spot eye problems early
Knowledge-focused Recruiting nowThis study looks at a new way to provide eye care to children in rural China. It will involve about 20,000 kids aged 3 to 18 from schools in several counties. The goal is to see if a coordinated program across local health centers and schools can improve eye screening rates and h…
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Researchers track vision changes in lazy eye patients during standard treatments
Knowledge-focused Recruiting nowThis study looks at how well people with amblyopia (lazy eye) or strabismus (crossed eyes) see before, during, and after common treatments like patching, glasses, or surgery. Researchers will measure things like sharpness, contrast, and reading ability. The goal is to better unde…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Study reveals eye issues in skull condition
Knowledge-focused Recruiting nowThis study looks at eye problems in people with craniosynostosis, a condition where skull bones close too early. Researchers will check for issues like crossed eyes, lazy eye, and pressure inside the head. The goal is to better understand these eye problems to help improve care.
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Massive gene hunt launched for eye and nerve disorders
Knowledge-focused Recruiting nowThis study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which c…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Scientists hunt for Eye-Misalignment genes
Knowledge-focused Recruiting nowThis study aims to find genetic variants linked to strabismus (crossed eyes) and nystagmus (involuntary eye movements). Researchers will analyze DNA from families with at least three members who have strabismus, or families with infantile esotropia or nystagmus. By comparing affe…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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New microscope camera could make eye surgery safer and more precise
Knowledge-focused Recruiting nowThis study tests a special microscope that takes live 3D images inside the eye during surgery. It aims to help surgeons see better when treating conditions like retinal detachment, macular holes, and cataracts. About 262 people will take part, including healthy volunteers and sur…
Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC