Strabismus
MONDO:0003432Strabismus is the intermittent or constant misalignment of an eye so that its line of vision is not pointed at the same object as the other eye. Strabismus is caused by an imbalance in the extraocular muscles which control the positioning of the eyes. Strabismus is normal in newborns but should resolve by the time the baby is 6 months old. In older children with strabismus, the brain may learn to ignore the input from one eye, and this may lead to amblyopia, a potentially permanent decrease in vision in that eye if not corrected.
Also known as: squint, strabismus
42 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Eye patch showdown: can Full-Time wear beat observation for wandering eyes?
Disease control CompletedThis study looked at whether wearing an eye patch full-time can improve control of intermittent exotropia (a type of eye misalignment) in children aged 3 to 9. Over 3 months, researchers compared patching to simply watching and waiting. The goal was to see if patching leads to be…
Phase: PHASE3 • Sponsor: Jaeb Center for Health Research • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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New headset therapy may reduce need for repeat eye surgeries in kids
Disease control CompletedThis study tests a non-surgical treatment for intermittent exotropia, a condition where one eye drifts outward. Children aged 4-7 will use a special headset for one hour daily, six days a week, for 12 weeks. The goal is to improve eye control and reduce the need for surgery.
Phase: NA • Sponsor: Virginia Commonwealth University • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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Eye muscle surgery showdown: which fix for wandering eyes works best?
Disease control CompletedThis trial compares two common surgical procedures for intermittent exotropia, a condition where one eye occasionally turns outward. Children aged 3 to 10 with basic or pseudo-divergence excess type exotropia are randomly assigned to receive either bilateral lateral rectus recess…
Phase: NA • Sponsor: Jaeb Center for Health Research • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Could stronger glasses tame wandering eyes in kids?
Disease control CompletedThis trial compares overminus spectacles (glasses with extra focusing power) to standard glasses in children aged 3 to 11 with intermittent exotropia, a condition where one eye occasionally drifts outward. The goal is to see if overminus lenses improve eye control over 12 months …
Phase: NA • Sponsor: Jaeb Center for Health Research • Aim: Disease control
Last updated Jul 11, 2026 00:00 UTC
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Eye muscle surgery showdown: which fix for wandering eyes works best?
Disease control CompletedThis study compared two surgical methods to correct exotropia, a condition where one eye turns outward. In one group, a piece of the inner eye muscle was removed and reattached; in the other, the muscle was folded and shortened. Both groups also had the outer eye muscle loosened.…
Phase: NA • Sponsor: Başakşehir Çam & Sakura City Hospital • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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Eye exercises after surgery may help keep eyes aligned
Disease control CompletedThis study looked at whether eye exercises after strabismus (crossed eyes) surgery help maintain eye alignment and control over time. Forty children aged 5 to 15 who had surgery and completed a 3-month exercise program were followed. Researchers measured eye deviation and control…
Sponsor: Amany Refaat Mohamed Abdel Wahid • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New eye muscle surgery shows promise for correcting outward strabismus
Disease control CompletedThis study tested a new surgical technique called lateral rectus muscle strangulation to treat exotropia, a condition where one or both eyes turn outward. Twelve people aged 4 and older with intermittent exotropia or exophoria underwent the procedure. The goal was to weaken the e…
Phase: NA • Sponsor: Sohag University • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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VR training shows promise for Kids' eye misalignment
Disease control CompletedThis study tested a virtual reality training program called Nu.T in 54 children aged 6 to 15 with intermittent exotropia, a condition where one eye occasionally turns outward. Half of the children used the Nu.T software to do visual exercises, while the other half received no tre…
Phase: NA • Sponsor: Nunaps Inc • Aim: Disease control
Last updated Jun 26, 2026 17:44 UTC
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Eye surgery showdown: which fix works best for crossed eyes?
Disease control CompletedThis study looked at two surgical methods to correct a type of eye misalignment called V-pattern intermittent exotropia, where the eyes drift outward, especially when looking up. Twenty patients received either a standard muscle recession or a recession with an upward shift of th…
Phase: NA • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 26, 2026 17:39 UTC
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Morning or evening patching for lazy eye? study seeks best timing
Symptom relief CompletedThis study tests whether patching the stronger eye in the morning (8-10 AM) or evening (5-7 PM) works better for improving vision in children with lazy eye (amblyopia). About 100 children aged 4-8 will wear an eye patch for 2-6 hours daily over 6 months. The goal is to see if tim…
Phase: NA • Sponsor: Yarmouk University • Aim: Symptom relief
Last updated Aug 06, 2026 00:00 UTC
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Can a simple drug stop kids from waking up confused after eye surgery?
Symptom relief CompletedThis study tests whether giving sugammadex (a drug that reverses muscle relaxants) can lower the chance of children waking up agitated after strabismus (eye muscle) surgery. About 76 children aged 4 to 7 will be randomly assigned to receive either sugammadex or a standard drug (n…
Phase: PHASE4 • Sponsor: Konkuk University Medical Center • Aim: Symptom relief
Last updated Jul 17, 2026 00:00 UTC
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Deeper anesthesia may shield Kids' hearts during strabismus surgery
Symptom relief CompletedThis study tested whether giving children a deeper level of muscle relaxation during strabismus (crossed eyes) surgery could prevent a sudden drop in heart rate, known as the oculocardiac reflex. The trial involved 201 children aged 3 to 18 years. Researchers compared two levels …
Phase: NA • Sponsor: Seoul National University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Which drug calms kids better after eye surgery?
Symptom relief CompletedThis trial tested two drugs, propofol and dexmedetomidine, to see which better prevents emergence agitation—a state of restlessness and crying—in children aged 3 to 7 after squint surgery. Eighty children were randomly given one of the drugs after anesthesia. The goal is to find …
Phase: PHASE4 • Sponsor: Ain Shams University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Small study reveals parents' struggles giving eye drops to toddlers after eye surgery
Knowledge-focused CompletedThis study interviewed 13 parents of children aged 2-6 who had strabismus (crossed eyes) surgery. Researchers wanted to understand how parents gave their children eye drops after surgery and how well the children cooperated. The goal is to learn from these experiences to improve …
Sponsor: Uludag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC