Could stronger glasses tame wandering eyes in kids?

NCT ID NCT02807350

Completed Disease control Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial compares overminus spectacles (glasses with extra focusing power) to standard glasses in children aged 3 to 11 with intermittent exotropia, a condition where one eye occasionally drifts outward. The goal is to see if overminus lenses improve eye control over 12 months of wear and whether any benefit lasts after stopping treatment. The study involves 386 participants and measures eye alignment using a standard scoring system.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Overminus spectacles
What this could lead to: If effective, overminus glasses could offer a non-surgical way to better control eye drifting in children with intermittent exotropia.
What could go wrong: This is a mid-stage trial; results may show no lasting benefit after treatment stops, and overminus glasses can cause eye strain or blurred vision.

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Conditions

The condition(s) this trial relates to.

alternating exotropia intermittent squint

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTERMITTENT EXOTROPIA

Contacts and locations

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Locations

Akron Children's Hospital

Akron, Ohio, 44308, United States
Alberta Children's Hospital

Calgary, Alberta, Canada
Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Arkansas Childrens

Little Rock, Arkansas, 72202, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CHU - Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
Casey Eye Institute

Portland, Oregon, 97239, United States
Children's Eye Care PC

West Bloomfield, Michigan, 48322, United States
Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States
Cincinnati Children's Hospital

Cincinnati, Ohio, 45229, United States
Concord Ophthalmologic Associates

Concord, New Hampshire, 03301, United States
Conestoga Eye

Lancaster, Pennsylvania, 17601, United States
Dean A. McGee Eye Institute, University of Oklahoma

Oklahoma City, Oklahoma, 73104, United States
Duke University Eye Center

Durham, North Carolina, 27710, United States
Eye Care Associates, Inc.

Poland, Ohio, 44514, United States
Greater Baltimore Medical Center

Baltimore, Maryland, 21204-5809, United States
Gundersen Health System

La Crosse, Wisconsin, 54601, United States
Helen DeVos Children's Hospital Pediatric Ophthalmology

Grand Rapids, Michigan, 49503, United States
Houston Eye Associates

The Woodlands, Texas, 77381, United States
Illinois College of Optometry

Chicago, Illinois, 60616, United States
Indiana University School Of Optometry

Bloomington, Indiana, 47405, United States
Loma Linda University Health Care, Dept. of Ophthalmology

Loma Linda, California, 92354, United States
Marshall B. Ketchum University

Fullerton, California, 92831, United States
Mayo Clinic Department of Ophthalmology

Rochester, Minnesota, 55905, United States
Medical University of South Carolina, Storm Eye Institute

Charleston, South Carolina, 29425, United States
Midwestern U Chicago College of Optometry

Downers Grove, Illinois, 60515, United States
Midwestern University Eye Institute

Glendale, Arizona, 85308, United States
Nemours Children's Clinic

Jacksonville, Florida, 32207, United States
Nova Southeastern University College of Optometry, The Eye Institute

Fort Lauderdale, Florida, 33382, United States
Pacific University College of Optometry

Portland, Oregon, 97205, United States
Pediatric Eye Associates

Wilmette, Illinois, 60091, United States
Pediatric Eye Specialists

Chattanooga, Tennessee, 37421, United States
Pediatric Ophthalmology, P.C.

Grand Rapids, Michigan, 49546, United States
Riley Hospital for Children

Indianapolis, Indiana, 46202, United States
Saddleback Eye Medical Associates

Mission Viejo, California, 92691, United States
Salus University/Pennsylvania College of Optometry

Philadelphia, Pennsylvania, 19141, United States
Southern College of Optometry

Memphis, Tennessee, 38104, United States
St Luke's Hospital

Boise, Idaho, 83702, United States
Stanford University

Palo Alto, California, 94303, United States
State University of New York, College of Optometry

New York, New York, 10036, United States
Texas Children's Hospital - Dept. Of Ophthalmology

Houston, Texas, 77030, United States
Texas Tech University Health Science Center

Lubbock, Texas, 79430, United States
The Emory Eye Center

Atlanta, Georgia, 30322, United States
The Eye Specialist Center, LLC

Munster, Indiana, 46321, United States
The Eye Specialists Center, LLC

Chicago Ridge, Illinois, 60415, United States
The Ohio State University College of Optometry

Columbus, Ohio, 43210-1280, United States
Tufts Medical Center

Boston, Massachusetts, 02111, United States
U of MO St. Louis College of Optometry

St Louis, Missouri, 63121, United States
UPMC Children's Eye Center of Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
University Eye Center at Ketchum Health

Anaheim, California, 92807, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of California San Francisco Department of Ophthalmology

San Francisco, California, 94143, United States
University of Florida Shands Hospital

Gainesville, Florida, 32608, United States
University of Houston College of Optometry

Houston, Texas, 77204, United States
University of Kentucky Department of Neurology

Lexington, Kentucky, 40536, United States
University of Minnesota

Minneapolis, Minnesota, 55454, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68114, United States
Virginia Pediatric Eye Center

Norfolk, Virginia, 23502, United States
Western University College of Optometry

Pomona, California, 91766, United States
Wilmer Eye Institute

Baltimore, Maryland, 21287-9028, United States
Wolfe Eye Clinic

West Des Moines, Iowa, 50266, United States

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