New hope for rare bone disease: first human trial of KK8123 begins
NCT ID NCT06525636
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. About 24 adults will receive the drug as a shot under the skin to see if it can safely raise phosphate levels and improve symptoms.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hoptial Bictre
RECRUITINGLe Kremlin-Bicêtre, Paris, 94275, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario La Paz
RECRUITINGMadrid, 28046, Spain
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Indiana University School of Medicine University Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Institute of Osteology and Biomechanics (IOBM)
RECRUITINGHamburg, 22529, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Mayo Clinic
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
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Universitaetsklinikum Wurzburg
RECRUITINGWürzburg, 97074, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California - San Francisco
RECRUITINGSan Francisco, California, 94158, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yale Center for XLH/ Yale University School of Medicine
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••