New hope for rare bone disease: first human trial of KK8123 begins

NCT ID NCT06525636

Recruiting now Disease control Sponsor: Kyowa Kirin Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called KK8123 for adults with X-linked hypophosphatemia (XLH), a rare genetic condition that causes low phosphate levels and bone problems. The trial has two parts: first, finding the right dose, then checking safety and how well it works over time. About 24 adults will receive the drug as a shot under the skin to see if it can safely raise phosphate levels and improve symptoms.

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Conditions

The condition(s) this trial relates to.

bone disorder hypophosphatemia kidney disorder metabolic disease musculoskeletal system disorder Rare Diseases X-linked dominant hypophosphatemic rickets X-linked hypophosphatemic rickets

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

X-LINKED HYPOPHOSPHATEMIA

Contacts and locations

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Locations

Hoptial Bictre
RECRUITING

Le Kremlin-Bicêtre, Paris, 94275, France
Hospital Universitario La Paz
RECRUITING

Madrid, 28046, Spain
Indiana University School of Medicine University Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States
Institute of Osteology and Biomechanics (IOBM)
RECRUITING

Hamburg, 22529, Germany
Mayo Clinic
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Universitaetsklinikum Wurzburg
RECRUITING

Würzburg, 97074, Germany
University of California - San Francisco
RECRUITING

San Francisco, California, 94158, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Yale Center for XLH/ Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

Contact Email: •••••@•••••

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