Lifelong enzyme therapy continues for hunter syndrome patients in Post-Trial access program

NCT ID NCT05795361

First seen Apr 21, 2026 · Last updated May 13, 2026 · Updated 4 times

Summary

This program offers continued access to idursulfase-IT (TAK-609) given directly into the spinal fluid, along with intravenous Elaprase, for children and adults with Hunter syndrome who have cognitive impairment. Participants must have completed one of two earlier studies. The goal is to maintain treatment for those who continue to benefit, as there is no cure and lifelong management is needed.

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Contacts and locations

Study contacts

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Locations

  • Ann and Robert H Lurie Childrens Hospital of Chicago

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    Chicago, Illinois, 60611, United States

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  • Board of Regents of the University of Nebraska

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    Omaha, Nebraska, 68198-5450, United States

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  • Division of Medical Genetics, University of Utah

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    Salt Lake City, Utah, 84112, United States

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  • H.C.U. de Valladolid

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    Valladolid, 47003, Mexico

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  • Hospital Universitario Reina Sofia

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    Córdoba, 14004, Spain

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  • Instituto Nacional de Pediatria

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    Coyoacán, Mexico City, 4530, Mexico

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  • Jackson Memorial Hospital University of Miami

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    Miami, Florida, 33101, United States

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  • Joseph M. Sanzari Children's Hospital

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    Hackensack, New Jersey, 07601, United States

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  • NYU Langone Medical Center

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    New York, New York, 10017, United States

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  • Phoenix Childrens Hospital

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    Phoenix, Arizona, 85015, United States

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  • Queensland Childrens Hospital

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    South Brisbane, Queensland, QLD 4101, Australia

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  • Randall Children's Hospital at Legacy Emanuel

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    Portland, Oregon, 97227, United States

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  • Royal Manchester Children's Hospital - PPDS

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    Manchester, M13 9WL, United Kingdom

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  • Seattle Children's Hospital - PIN

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    Seattle, Washington, 98105, United States

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  • The Children's Hospital of Philadelphia

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    Philadelphia, Pennsylvania, 19104, United States

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  • The Cleveland Clinic Foundation

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    Cleveland, Ohio, 44195, United States

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  • The Nemours Foundation

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    Wilmington, Delaware, 19803, United States

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  • The Regents of the University of California

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    Oakland, California, 94609, United States

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  • The University of North Carolina

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    Chapel Hill, North Carolina, 27514, United States

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  • UPMC Childrens Hospital of Pittsburgh

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    Pittsburgh, Pennsylvania, 15224, United States

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  • Vanderbilt Children's Hospital

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    Nashville, Tennessee, 37232-7610, United States

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  • Washington University

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    Washington, Missouri, 63130, United States

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Conditions

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