New pill could help kids with dwarfism grow – but early days

NCT ID NCT06842355

Recruiting now Disease control Sponsor: Tyra Biosciences, Inc Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 9 times

Summary

This study tests a daily oral drug called TYRA-300 in 92 children aged 3–10 with achondroplasia (a common form of dwarfism). The goal is to see if it safely increases their growth rate. Researchers will try different doses to find the best one. It's a Phase 2 trial, so it's still early and not yet proven to work.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: TYRA-300 (an oral drug taken daily)
What this could lead to: If successful, this could lead to a daily pill that helps children with achondroplasia grow taller, potentially reducing some health complications.
What could go wrong: This is an early Phase 2 trial with only 92 children, so results may not apply to everyone. The drug may cause side effects or fail to improve growth significantly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

achondroplasia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACHONDROPLASIA

Contacts and locations

Locations

Astrid Lindgren Children's Hospital (Karolinska University Hospital)
RECRUITING

Stockholm, Sweden
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Eastern Ontario
RECRUITING

Ottawa, Ontario, K1H 8L1, Canada
Children's Medical Center, Dallas
RECRUITING

Dallas, Texas, 75235, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Great Ormond Street Hospital
RECRUITING

London, Greater London, WC1N 3JH, United Kingdom
Hospital Univeristario La Paz
RECRUITING

Madrid, Madrid, 28046, Spain
Imagine Institute
RECRUITING

Paris, 75015, France
Johns Hopkins University School of Medicine
RECRUITING

Baltimore, Maryland, 21205, United States
Lundquist Institute for Biomedical Innovation
RECRUITING

Torrance, California, 90502, United States
Nemours Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Sheffield Children's Hospital
RECRUITING

Sheffield, South Yorkshire, S10 2TH, United Kingdom
The Children's Hospital at Westmead
RECRUITING

Westmead, New South Wales, 2145, Australia
The Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G1X8, Canada
UMC Utrecht
RECRUITING

Utrecht, 3584 CX, Netherlands
Uncommon Cures
RECRUITING

Chevy Chase, Maryland, 20815, United States
Unidad de Cirugía Artroscópica (MIKS Hospital)
RECRUITING

Vitoria-Gasteiz, Alava, 1008, Spain
University of Missouri
RECRUITING

Columbia, Missouri, 65201, United States
University of Texas Health Science Center Medical School at Houston
RECRUITING

Houston, Texas, 77030, United States
University of Wisconsin-Madison
RECRUITING

Madison, Wisconsin, 53715, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University
RECRUITING

St Louis, Missouri, 63130, United States
Women's and Children's Health Research Institute, University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2R3, Canada

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