New shot aims to fortify fragile bones in brittle bone disease trial
NCT ID NCT07062588
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 12 months, which could lead to stronger bones and fewer fractures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
AGA2115 (a drug given as a shot under the skin)
What this could lead to
If it works, this could point toward a new treatment to strengthen bones and reduce fractures in people with brittle bone disease.
What could go wrong
This is an early Phase 2 trial with only 80 people, so results may not apply to everyone. The drug may not improve bone density more than placebo, and side effects are still being studied.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Aarhus Universitetshospital - Medicinsk Endokrinologisk Afdeling (MEA) Ambulatoriet - Tage-Hansens Gade
NOT_YET_RECRUITINGAarhus, Denmark
Contact
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Adults Westmead Hospital
NOT_YET_RECRUITINGWestmead, Australia
Contact
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Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Lariboisiere
NOT_YET_RECRUITINGParis, France
Contact
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Cambridge University Hospitals NHS Foundation Trust-Addenbrooke's Hospital
NOT_YET_RECRUITINGCambridge, United Kingdom
Contact
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Erasmus MC
NOT_YET_RECRUITINGRotterdam, Netherlands
Contact
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Hopital Edouard Herriot
NOT_YET_RECRUITINGLyon, France
Contact
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Indiana University School of Medicine, Department of Medicine and Pediatrics Division of Endocrinology
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
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Instituto de Investigaciones Metabolicas Dr. Zanchetta - Sede Centro
RECRUITINGBuenos Aires, Argentina
Contact
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Isala ziekenhuizen
NOT_YET_RECRUITINGZwolle, Netherlands
Contact
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Leiden University Medical Center (LUMC) - Centrum voor botkwaliteit
NOT_YET_RECRUITINGLeiden, Netherlands
Contact
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Lothian Health Board, Western General Hospital
NOT_YET_RECRUITINGEdinburgh, United Kingdom
Contact
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Monash University-Monash Medical Centre (MMC)
NOT_YET_RECRUITINGMelbourne, Australia
Contact
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Nemours/Alfred I. duPont Hospital for Children
NOT_YET_RECRUITINGWilmington, Delaware, 19803, United States
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New Mexico Clinical Research & Osteoporosis Center, Inc. (NMCROC)
RECRUITINGAlbuquerque, New Mexico, 87160, United States
Contact
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Odense Universitetshospital
NOT_YET_RECRUITINGOdense, Denmark
Contact
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Oregon Health & Science University (OHSU) - The Harold Schnitzer Diabetes Health Center (HSDHC) - Endocrinology Clinic
NOT_YET_RECRUITINGPortland, Oregon, 97239, United States
Contact
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Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITINGOxford, United Kingdom
Contact
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Phoenix Children's
RECRUITINGPhoenix, Arizona, 85016, United States
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Royal Melbourne Hospital
NOT_YET_RECRUITINGParkville, Australia
Contact
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Royal National Orthopaedic Hospital NHS Trust
NOT_YET_RECRUITINGLondon, United Kingdom
Contact
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Royal North Shore Hospital (RNSH)
NOT_YET_RECRUITINGSaint Leonards, Australia
Contact
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The Ohio State University Wexner Medical Center (OSUWMC)
NOT_YET_RECRUITINGColumbus, Ohio, 43210, United States
Contact
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University Health Network - Toronto General Hospital - Osteoporosis Clinic
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact
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University of Nebraska Medical Center (UNMC) - Diabetes and Endocrinology Center
NOT_YET_RECRUITINGOmaha, Nebraska, 68131, United States
Contact
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Vanderbilt University Medical Center (VUMC) - Eskind Diabetes Clinic
NOT_YET_RECRUITINGNashville, Tennessee, 37232, United States
Contact
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Washington University School of Medicine in St. Louis
NOT_YET_RECRUITINGSt Louis, Missouri, 63110, United States
Contact
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Yale University School of Medicine
NOT_YET_RECRUITINGNew Haven, Connecticut, 06510, United States
Contact