New shot aims to fortify fragile bones in brittle bone disease trial

NCT ID NCT07062588

Recruiting now Disease control Sponsor: Angitia Incorporated Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study tests a drug called AGA2115 in 80 adults with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to see if the drug increases bone density in the spine after 12 months, which could lead to stronger bones and fewer fractures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AGA2115 (a drug given as a shot under the skin)
What this could lead to: If it works, this could point toward a new treatment to strengthen bones and reduce fractures in people with brittle bone disease.
What could go wrong: This is an early Phase 2 trial with only 80 people, so results may not apply to everyone. The drug may not improve bone density more than placebo, and side effects are still being studied.

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Conditions

The condition(s) this trial relates to.

osteogenesis imperfecta osteogenesis imperfecta type 1 osteogenesis imperfecta type 3 osteogenesis imperfecta type 4

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOGENESIS IMPERFECTA (OI)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Aarhus Universitetshospital - Medicinsk Endokrinologisk Afdeling (MEA) Ambulatoriet - Tage-Hansens Gade
NOT_YET_RECRUITING

Aarhus, Denmark
Adults Westmead Hospital
NOT_YET_RECRUITING

Westmead, Australia
Assistance Publique-Hopitaux de Paris (AP-HP) - Hopital Lariboisiere
NOT_YET_RECRUITING

Paris, France
Cambridge University Hospitals NHS Foundation Trust-Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, United Kingdom
Erasmus MC
NOT_YET_RECRUITING

Rotterdam, Netherlands
Hopital Edouard Herriot
NOT_YET_RECRUITING

Lyon, France
Indiana University School of Medicine, Department of Medicine and Pediatrics Division of Endocrinology
RECRUITING

Indianapolis, Indiana, 46202, United States
Instituto de Investigaciones Metabolicas Dr. Zanchetta - Sede Centro
RECRUITING

Buenos Aires, Argentina
Isala ziekenhuizen
NOT_YET_RECRUITING

Zwolle, Netherlands
Leiden University Medical Center (LUMC) - Centrum voor botkwaliteit
NOT_YET_RECRUITING

Leiden, Netherlands
Lothian Health Board, Western General Hospital
NOT_YET_RECRUITING

Edinburgh, United Kingdom
Monash University-Monash Medical Centre (MMC)
RECRUITING

Melbourne, Australia
Nemours/Alfred I. duPont Hospital for Children
NOT_YET_RECRUITING

Wilmington, Delaware, 19803, United States
New Mexico Clinical Research & Osteoporosis Center, Inc. (NMCROC)
RECRUITING

Albuquerque, New Mexico, 87160, United States
Odense Universitetshospital
NOT_YET_RECRUITING

Odense, Denmark
Oregon Health & Science University (OHSU) - The Harold Schnitzer Diabetes Health Center (HSDHC) - Endocrinology Clinic
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Oxford University Hospitals NHS Foundation Trust
NOT_YET_RECRUITING

Oxford, United Kingdom
Phoenix Children's
RECRUITING

Phoenix, Arizona, 85016, United States
Royal Melbourne Hospital
RECRUITING

Parkville, Australia
Royal National Orthopaedic Hospital NHS Trust
NOT_YET_RECRUITING

London, United Kingdom
Royal North Shore Hospital (RNSH)
RECRUITING

Saint Leonards, Australia
The Ohio State University Wexner Medical Center (OSUWMC)
NOT_YET_RECRUITING

Columbus, Ohio, 43210, United States
University Health Network - Toronto General Hospital - Osteoporosis Clinic
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
Vanderbilt University Medical Center (VUMC) - Eskind Diabetes Clinic
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine in St. Louis
NOT_YET_RECRUITING

St Louis, Missouri, 63110, United States
Yale University School of Medicine
RECRUITING

New Haven, Connecticut, 06510, United States

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