New drug aims to slash fractures in brittle bone disease

NCT ID NCT05125809

Ongoing Disease control Sponsor: Ultragenyx Pharmaceutical Inc Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a medicine called setrusumab in people with osteogenesis imperfecta (brittle bone disease). The goal is to see if it can lower the number of bone fractures. About 183 participants with types I, III, or IV of the disease who have had recent fractures will receive either the drug or a placebo. The study is in phases 2 and 3, meaning it checks both the right dose and how well it works compared to no treatment.

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Conditions

The condition(s) this trial relates to.

osteogenesis imperfecta osteogenesis imperfecta type 1 osteogenesis imperfecta type 3 osteogenesis imperfecta type 4

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOGENESIS IMPERFECTA

Contacts and locations

Locations

Arkansas Children's Hospital

Little Rock, Arkansas, 72202, United States
Atrium Health Levine Children's Hospital

Charlotte, North Carolina, 28203, United States
Azienda Ospedaliera Universitaria Policlinico Umberto I

Rome, 00161, Italy
Baylor College of Medicine

Houston, Texas, 77030, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Centro Hospitalar do Porto

Porto, 4099-001, Portugal
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital and Medical Center

Omaha, Nebraska, 68114, United States
Children's Hospital of Eastern Ontario

Ottawa, Ontario, K1H 8L1, Canada
Children's National Medical Center

Washington D.C., District of Columbia, 20010, United States
Connecticut Children's Medical Center

Hartford, Connecticut, 06106, United States
Cook Children's Medical Center

Fort Worth, Texas, 76104, United States
Gazi University

Ankara, Turkey (Türkiye)
Hospital de Santa Maria

Lisbon, 1649-028, Portugal
Indiana University Hospital

Indianapolis, Indiana, 46202, United States
Institut Imagine

Paris, France
Istituto Ortopedico Rizzoli

Bologna, Italy
Kennedy Krieger Institute

Baltimore, Maryland, 21205, United States
London Health Sciences Center

London, Ontario, Canada
Marmara University

Istanbul, Turkey (Türkiye)
McGill University Health Centre

Montreal, H4A 3J1, Canada
Musculoskeletal Center Würzburg

Würzburg, 97074, Germany
Nationwide Children's Hospital- Ohio State University College of Medicine

Columbus, Ohio, 43205, United States
Nemours/ Alfred i. duPoint Hospital for Children

Wilmington, Delaware, 19803, United States
New Mexico Clinical Research & Osteoporosis Center, Inc.

Albuquerque, New Mexico, 87106, United States
Otto von Guericke University Magdeburg

Magdeburg, 39106, Germany
Queensland Paediatric Endocrinology

South Brisbane, Queensland, QLD 4101, Australia
Royal Children's Hospital

Melbourne, Australia
Royal Manchester Childrens Hospital

Manchester, United Kingdom
Sheffield Children's NHS Foundation Trust

Sheffield, S10 2TH, United Kingdom
Shriners Hospital for Children - Northern California

Sacramento, California, 95817, United States
Shriners Hospitals for Children - Chicago

Chicago, Illinois, 60707, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
UW Health University Hospital

Madison, Wisconsin, 53792, United States
Universita Degli Studi Di Verona

Verona, Italy
University of Cologne

Cologne, Germany
University of South Florida

Tampa, Florida, 33612, United States
University of Toronto- The Hospital for Sick Children (SickKids)

Toronto, Canada
Uniwersytet Medyczny w Lodzi - Klinika Endokrynologii i Chorob Metabolicznych

Lodz, Poland
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wilhelmina Children's Hospital

Utrecht, Netherlands
Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

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