OSTEOGENESIS IMPERFECTA

This study follows children and teenagers with osteogenesis imperfecta (brittle bone disease) who previously received the drug romosozumab in an earlier trial. The goal is to monitor their long-term safety by tracking any side effects. No new treatment is given—just observation. …

This study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in 106 children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab reduces the number of…

This study tests whether a 6-month adapted physical activity program can improve endurance and quality of life in 30 children and teens with osteogenesis imperfecta (brittle bone disease). Participants will do supervised exercises designed for their condition. The main goal is to…

This study tests whether bisphosphonates, drugs often used for bone health, can improve hearing loss in people with Osteogenesis Imperfecta (OI), also known as brittle bone disease. The researchers will enroll 100 adults and children with OI, some receiving the drug and others no…

This study is building a large database of information from up to 5,000 people with osteogenesis imperfecta (brittle bone disease). Researchers will collect medical history, genetic data, and quality-of-life details to better understand how the disease progresses and how it affec…

This study looks at whether children and young adults (ages 12-20) with osteogenesis imperfecta (brittle bone disease) have problems with hearing and balance. Participants will undergo hearing tests and balance assessments. The goal is to find links between the genetic type and s…

This study looks at heart structure and function in people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers want to learn how often heart problems occur in people with OI and how they change over time. The goal is to help doctors screen for hea…

This study tests a new, safe ultrasound technology called REMS to measure bone density in children aged 5 to 18 who have conditions that weaken bones, like brittle bone disease or osteoporosis. Unlike standard X-ray methods, REMS uses no radiation. The goal is to see how well REM…