OSTEOGENESIS IMPERFECTA
Clinical trials for OSTEOGENESIS IMPERFECTA explained in plain language.
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Brittle bone breakthrough? new combo aims to cut fractures in OI
Disease control CompletedThis study tested whether a two-year course of teriparatide followed by a single infusion of zoledronic acid can reduce fractures in adults with osteogenesis imperfecta (brittle bone disease). 350 participants were randomly assigned to receive either the drug combo or standard ca…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE4 • Sponsor: University of Edinburgh • Aim: Disease control
Last updated May 17, 2026 02:33 UTC
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New nail study aims to help kids with fragile bones
Disease control CompletedThis study looked at a special telescopic nail (JuniOrtho) used to fix broken bones or straighten bent bones in children with osteogenesis imperfecta (brittle bone disease). Researchers tracked 14 children to see how safe the nail is and how well it works over time. The goal was …
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Orthofix s.r.l. • Aim: Disease control
Last updated May 17, 2026 02:25 UTC
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Gentle exercise boosts health in kids with brittle bones
Symptom relief CompletedThis study looked at whether a personalized, supervised exercise program could help children and teens (ages 6-18) with osteogenesis imperfecta, a rare condition that causes fragile bones. Over one year, 30 participants followed an adaptive physical activity plan designed to be s…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated May 17, 2026 02:35 UTC
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Long-Term study aims to unlock secrets of brittle bone disease
Knowledge-focused CompletedThis study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to learn how the condition affects their bodies over time. Researchers tracked bone health, movement, heart and lung function, hearing, and brain issues. The goal…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 17, 2026 02:35 UTC
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Watching brittle bone disease: new study tracks kids to unlock OI's secrets
Knowledge-focused CompletedThis study followed 46 children with osteogenesis imperfecta (OI), a condition that causes fragile bones and short stature, to understand how the disease progresses and how genes affect it. Participants had regular checkups, scans, and tests over several years, but no new treatme…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 17, 2026 02:26 UTC
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Researchers study bone disorders to improve diagnosis and training
Knowledge-focused CompletedThis study evaluated people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was not to test new treatments but to learn more about these conditions, improve doctor training, and collect samples for fut…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated May 15, 2026 11:54 UTC
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Scientists hunt for hidden switches that make brittle bones worse or milder
Knowledge-focused CompletedThis study looked at 66 adults to find small molecules called microRNAs in the blood that might explain why some people with osteogenesis imperfecta (brittle bone disease) have a mild form while others have a severe form. Researchers compared people with type 1 (mild) and type 3 …
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Apr 24, 2026 16:19 UTC