OSTEOGENESIS IMPERFECTA

This study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta, also known as brittle bone disease. 350 participants were…

This study looked at how well a special telescopic nail (JuniOrtho) works and how safe it is in children with osteogenesis imperfecta (brittle bone disease). Fourteen children aged 18 months to 18 years who needed surgery for broken bones or bone straightening took part. The main…

This study looked at whether a supervised, adapted exercise program can improve fitness and quality of life in children aged 6 to 18 with osteogenesis imperfecta, a rare genetic condition causing fragile bones. Thirty participants did 30-minute exercise sessions twice a week for …

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This completed study enrolled 33 people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers used special sensors and gait analysis to measure how participants move. The goal was to identify which movement patterns are most useful for understanding…

This study followed 46 children with osteogenesis imperfecta (OI), a rare connective tissue disorder that causes frequent fractures and short stature. Researchers collected medical history, physical exams, hearing and dental tests, X-rays, bone scans, and genetic samples over sev…

This study looked at 66 adults with Osteogenesis Imperfecta (brittle bone disease) to see if small molecules called microRNAs in the blood are linked to how severe the condition is. Researchers compared people with mild (type 1) and severe (type 3) forms, plus healthy controls. T…