Researchers track rare bone disorder in kids to uncover clues

This study followed 46 children with osteogenesis imperfecta (OI), a rare connective tissue disorder that causes frequent fractures and short stature. Researchers collected medical history, physical exams, hearing and dental tests, X-rays, bone scans, and genetic samples over several years. The goal was to learn how the disease progresses and how specific gene changes relate to symptoms, without testing any new treatment.