OSTEOGENESIS IMPERFECTA
Clinical trials for OSTEOGENESIS IMPERFECTA explained in plain language.
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New drug trial aims to strengthen brittle bones and cut fracture risk
Disease control OngoingThis study is testing an investigational drug called setrusumab to see if it can reduce the number of broken bones in people with osteogenesis imperfecta (OI), also known as brittle bone disease. The trial involves about 183 participants, who will receive either setrusumab or a p…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE2, PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Clear aligners offer new hope for smiles in brittle bone disease
Disease control OngoingThis study is testing whether Invisalign clear aligners are a safe and effective way to straighten teeth for people with Osteogenesis Imperfecta (OI), also known as brittle bone disease. Traditional braces are often too risky for people with OI because their tooth enamel is fragi…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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New hope for kids with brittle bones: trial tests potential breakthrough treatment
Disease control OngoingThis study aims to see if a new medicine called setrusumab works better than the current standard treatment (bisphosphonates) at reducing broken bones in children with osteogenesis imperfecta, also known as brittle bone disease. Children aged 2 to under 7 with specific types of t…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Mar 30, 2026 14:32 UTC
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Pioneering trial tests stem cells in utero to fight devastating brittle bone disease
Disease control OngoingThis early-stage trial is testing whether stem cells from a donor, given to infants before or after birth, are safe and can help treat severe osteogenesis imperfecta (brittle bone disease). The study involves up to 18 infants and compares them to children who did not receive this…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE1, PHASE2 • Sponsor: Karolinska Institutet • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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New drug trial aims to stop fractures in kids with brittle bones
Disease control OngoingThis study is testing whether a drug called setrusumab can reduce the number of broken bones in Japanese children with osteogenesis imperfecta (OI), also known as brittle bone disease. Six children with specific types of OI will receive the drug for up to two years, with the opti…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated Mar 18, 2026 14:41 UTC
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Researchers map dental challenges in brittle bone disease
Knowledge-focused OngoingThis study aims to better understand dental and jaw alignment problems in people with moderate to severe Osteogenesis Imperfecta (brittle bone disease). Researchers will use 3D scans and X-rays to measure teeth misalignment and neck defects in 75 participants over time. The goal …
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Apr 01, 2026 22:56 UTC
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Simple pee test could revolutionize diagnosis for brittle bone disease
Knowledge-focused OngoingThis study aims to see if a new urine test can help doctors better understand and classify different types of Osteogenesis Imperfecta (OI), a rare condition that makes bones break easily. Researchers will collect urine samples from 25 people with OI who have specific genetic muta…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Apr 01, 2026 14:41 UTC
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Scientists investigate why breathing fails in brittle bone disease
Knowledge-focused OngoingThis study aims to understand why people with osteogenesis imperfecta (brittle bone disease) often develop serious breathing problems. Researchers will examine 18 adults with the condition through medical history, questionnaires, physical exams, and lung imaging tests. The goal i…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Mar 20, 2026 14:48 UTC