OSTEOGENESIS IMPERFECTA

This phase 3 study tests setrusumab, a monthly IV infusion, in 6 Japanese children with osteogenesis imperfecta (types I, III, or IV), a condition that causes fragile bones and frequent fractures. The main goal is to see if the drug lowers the number of fractures, including spine…

This study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab can reduce the number of …

This study tests a medicine called setrusumab in people with osteogenesis imperfecta (brittle bone disease). The goal is to see if it can lower the number of bone fractures. About 183 participants with types I, III, or IV of the disease who have had recent fractures will receive …

This study tests a new medicine called setrusumab against standard bone-strengthening drugs (bisphosphonates) in children aged 2 to under 7 with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if setrusumab can lower the number of bone break…

This early-phase trial tests whether fetal stem cells given before or after birth can safely help infants with severe osteogenesis imperfecta, a genetic condition causing fragile bones and frequent fractures. Up to 18 children will receive multiple doses of the cells. The main go…

This study tests whether Invisalign clear aligners can safely straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and dental work risky. About 57 participants aged 12 to 40 with mild to moderate teeth misalignment will receive treatm…

This study examines lung and heart function in 18 adults with osteogenesis imperfecta (OI), also known as brittle bone disease. Researchers want to understand why breathing problems are the leading cause of death in OI. Participants will undergo lung function tests and chest imag…

This study looks at teeth misalignment and neck defects in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans of the teeth, jaw, and neck to measure these problems in 75 participants aged 10 …

This study is testing whether a urine test can help identify different genetic types of osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will measure certain collagen peptides in the urine of 25 people with OI. If successful, this coul…