OSTEOGENESIS IMPERFECTA
Clinical trials for OSTEOGENESIS IMPERFECTA explained in plain language.
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Brittle bone breakthrough? new drug aims to slash fractures
Disease control OngoingThis study tests a drug called setrusumab in 183 people with osteogenesis imperfecta (brittle bone disease) to see if it can reduce how often bones break. Participants receive either the drug or a placebo, and researchers measure fracture rates and bone health markers. The goal i…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE2, PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 17, 2026 03:26 UTC
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New drug aims to cut fractures in kids with brittle bones
Disease control OngoingThis study tests a new medicine called setrusumab against standard bone-strengthening drugs (bisphosphonates) in children aged 2 to under 7 with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if setrusumab can lower the number of broken bon…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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New drug aims to cut fractures in kids with brittle bones
Disease control OngoingThis study tests a drug called setrusumab in Japanese children with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if it lowers the number of bone fractures, including spine fractures. Participants must have had at least one fracture in the…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE3 • Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Disease control
Last updated May 14, 2026 12:03 UTC
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Fetal stem cells offer hope for babies with brittle bones
Disease control OngoingThis study tests whether infusions of donated fetal stem cells can safely help babies with a severe form of osteogenesis imperfecta (brittle bone disease). The treatment aims to reduce fractures and improve bone strength. The trial includes up to 18 children, some treated before …
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: PHASE1, PHASE2 • Sponsor: Karolinska Institutet • Aim: Disease control
Last updated Apr 28, 2026 13:02 UTC
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Invisalign offers hope for safer smiles in brittle bone disease
Symptom relief OngoingThis study tests whether Invisalign clear aligners can safely straighten teeth in people with Osteogenesis Imperfecta (OI), a condition that makes bones brittle and dental work risky. About 57 participants aged 12 to 40 with mild to moderate dental misalignment will receive treat…
Matched conditions: OSTEOGENESIS IMPERFECTA
Phase: NA • Sponsor: Baylor College of Medicine • Aim: Symptom relief
Last updated May 14, 2026 12:06 UTC
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Brittle bones, broken smiles: new study looks at dental trouble in OI
Knowledge-focused OngoingThis study looks at teeth misalignment and neck problems in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans of the teeth, jaw, and neck to measure these issues in 75 participants aged 10 a…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC
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Brittle bone disease study aims to uncover hidden lung risks
Knowledge-focused OngoingThis study looks at how osteogenesis imperfecta (brittle bone disease) affects the heart and lungs. Researchers will measure lung function and use CT scans in 18 adults to find out why breathing problems are the leading cause of death in this condition. No new treatment is being …
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 14, 2026 12:06 UTC
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Pee power: urine test may replace needles for brittle bone diagnosis
Knowledge-focused OngoingThis study explores whether measuring certain collagen peptides in urine can help doctors tell apart the many genetic types of osteogenesis imperfecta (OI), a rare condition that makes bones break easily. Researchers will compare urine samples from 25 people with different OI gen…
Matched conditions: OSTEOGENESIS IMPERFECTA
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated May 07, 2026 18:42 UTC