New drug aims to cut fractures in kids with brittle bones
NCT ID NCT05768854
First seen Dec 10, 2025 · Last updated May 14, 2026 · Updated 20 times
Summary
This study tests a new medicine called setrusumab against standard bone-strengthening drugs (bisphosphonates) in children aged 2 to under 7 with osteogenesis imperfecta (brittle bone disease) types I, III, or IV. The goal is to see if setrusumab can lower the number of broken bones, including spine fractures. About 69 children who have had at least one fracture in the past year will take part.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Azienda Ospedaliera Universitaria Policlinico Umberto I
Roma, 00161, Italy
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Baylor College of Medicine
Houston, Texas, 77030, United States
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital at London Health Sciences Centre
London, Ontario, N6A 5W9, Canada
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Children's National Hospital DC
Washington D.C., District of Columbia, 20010, United States
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Childrens Hospital LA
Los Angeles, California, 90027, United States
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Childrens Hospital Of Eastern Ontario Research Institute, University Of Ottawa
Ottawa, KIH 8L1, Canada
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Cook Children's Medical Center
Fort Worth, Texas, 76104, United States
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Hospital de Clinicas de Porto Alegre (HCPA)
Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
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Institut Imagine
Paris, 75015, France
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Nemours/ Alfred i. duPoint Hospital for Children
Wilmington, Delaware, 19803, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85206, United States
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Shriners Hospitals for Children Chicago
Chicago, Illinois, 60707, United States
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Universitair Medisch Centrum Utrecht (UMCU) - Wilhelmina Kinderziekenhuis
Utrecht, 3584 EA, Netherlands
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University of North Carolina at Chapel Hill (UNC)
Chapel Hill, North Carolina, 27599, United States
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University of South Florida
Tampa, Florida, 33612, United States
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Uniwersytet Medyczny w Lodzi - Klinika Endokrynologii i Chorob Metabolicznych
Lodz, 91-738, Poland
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Vanderbilt University Medical Center (VUMC)
Nashville, Tennessee, 37212, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Yale New Haven Hospital
New Haven, Connecticut, 06510, United States
Conditions
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