Pee power: urine test may replace needles for brittle bone diagnosis

NCT ID NCT02531087

First seen Dec 16, 2025 · Last updated May 07, 2026 · Updated 14 times

Summary

This study explores whether measuring certain collagen peptides in urine can help doctors tell apart the many genetic types of osteogenesis imperfecta (OI), a rare condition that makes bones break easily. Researchers will compare urine samples from 25 people with different OI gene mutations. If successful, this could lead to a simpler, less invasive way to classify OI than current blood or skin biopsies.

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Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Hospital for Special Surgery

    New York, New York, 10021, United States

  • Oregon Health Science University

    Portland, Oregon, 97239, United States

  • Shriners Hospital for Children

    Milwauke, Wisconsin, 53201, United States

  • Shriners Hospital for Children

    Montreal, Quebec, H3G 1A6, Canada

  • University of California Los Angeles

    Los Angeles, California, 90095, United States

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

Conditions

Explore the condition pages connected to this study.