Brittle bone disease linked to severe teeth misalignment – new study investigates

NCT ID NCT02934451

Ongoing Knowledge-focused Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at teeth misalignment and neck defects in people with moderate to severe osteogenesis imperfecta (OI), a rare condition that causes bones to break easily. Researchers will use scans of the teeth, jaw, and neck to measure these problems in 75 participants aged 10 and older. The goal is to better understand dental issues in OI to improve quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could point toward better dental treatments for people with OI, improving chewing and quality of life.
What could go wrong: This is an observational study, not a treatment trial. It only measures problems, so it won't directly provide a new therapy. Results may not apply to all OI types.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteogenesis imperfecta

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOGENESIS IMPERFECTA

Contacts and locations

Locations

Baylor College of Medicine

Houston, Texas, 77030, United States
Shriners Hospital for Children

Montreal, Quebec, H3G 1A6, Canada
University of California Los Angeles

Los Angeles, California, 90095, United States

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