Breathing problems in brittle bone disease: new study seeks answers

NCT ID NCT05317637

Ongoing Knowledge-focused Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examines lung and heart function in 18 adults with osteogenesis imperfecta (OI), also known as brittle bone disease. Researchers want to understand why breathing problems are the leading cause of death in OI. Participants will undergo lung function tests and chest imaging to measure lung capacity and airway health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could reveal why people with osteogenesis imperfecta often have breathing issues, pointing toward future treatments.
What could go wrong: This is an observational study with only 18 participants, so findings may not apply to everyone with OI. It does not test any treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteogenesis imperfecta

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOGENESIS IMPERFECTA

Contacts and locations

Locations

Hospital for Special Surgery

New York, New York, 10021, United States
Kennedy Krieger Institute / Hugo W. Moser Research Institute

Baltimore, Maryland, 21205, United States
University of California Los Angeles

Los Angeles, California, 90095, United States

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