New drug aims to slash fractures in kids with brittle bones
NCT ID NCT05972551
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab can reduce the number of fractures and improve bone density over 12 months. About 111 participants will be randomly assigned to one of the two treatments.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Boston Childrens Hospital
Boston, Massachusetts, 02115, United States
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Centermed Krakow Sp zoo
Krakow, 31-530, Poland
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Centre Hospitalier Regional Universitaire de Lille
Lille, 59037, France
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Centre Hospitalier Universitaire Sainte Justine
Montreal, Quebec, H3T 1C5, Canada
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Centre Hospitalier Universitaire Vaudois
Lausanne, 1011, Switzerland
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Centre Hospitalier Universitaire de Bordeaux - Hopital Pellegrin
Bordeaux, 33076, France
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Centro Ricerche Cliniche Di Verona Societa responsabilita limitata
Verona, 37134, Italy
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Centrum Medyczne Medyk Spolka z Ograniczona Odpowiedzialnoscia Spolka Komandytowa
Rzeszów, 35-326, Poland
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Childrens Hospital of Alabama
Birmingham, Alabama, 35233, United States
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Childrens Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
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Childrens Hospital of Soochow University
Suzhou, Jiangsu, 215000, China
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Ege Universitesi Tip Fakultesi Hastanesi
Izmir, 35100, Turkey (Türkiye)
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Emory University
Atlanta, Georgia, 30322, United States
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Gazi Universitesi Saglik Arastirma ve Uygulama Merkezi Gazi Hastanesi
Ankara, 06500, Turkey (Türkiye)
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Gillette Childrens Hospital and Clinic Saint Paul
Saint Paul, Minnesota, 55101, United States
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Hopital Necker Enfants Malades
Paris, 75743, France
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Hospital Sant Joan de Deu
Esplugues de Llobregat, Catalonia, 08950, Spain
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Hospital Universitari Vall d Hebron
Barcelona, Catalonia, 08035, Spain
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Hospital Universitari i Politecnic La Fe
Valencia, Valencia, 46026, Spain
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Hospital Universitario Infantil Niño Jesus
Madrid, 28009, Spain
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Hospital Universitario de Getafe
Getafe, Madrid, 28905, Spain
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Hospital de Cruces
Barakaldo, Basque Country, 48903, Spain
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IRCCS Istituto Giannina Gaslini
Genova, 16147, Italy
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Indiana University
Indianapolis, Indiana, 46202, United States
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Instytut Centrum Zdrowia Matki Polki
Lodz, 93-338, Poland
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Karadeniz Teknik Universitesi Tip Fakultesi
Trabzon, 61080, Turkey (Türkiye)
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Kennedy Krieger Institute
Baltimore, Maryland, 21287, United States
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Kepler Universitaetsklinikum GmbH
Linz, 4020, Austria
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King Faisal Specialist Hospital and Research Centre
Riyadh, 11564, Saudi Arabia
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Marmara Universitesi Tip Fakultesi Hastanesi
Istanbul, 34890, Turkey (Türkiye)
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Marshfield Clinic
Marshfield, Wisconsin, 54449, United States
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Mayo Clinic Childrens Center
Rochester, Minnesota, 55905, United States
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Monash Childrens Hospital
Clayton, Victoria, 3168, Australia
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Narodny ustav detskych chorob
Bratislava, 833 40, Slovakia
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National Center for Child Health and Development
Setagaya-ku, Tokyo, 157-8535, Japan
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Nemours Childrens Hospital
Orlando, Florida, 32827, United States
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Nemours Hospital for Children
Wilmington, Delaware, 19803, United States
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Okayama Saiseikai Outpatient Center Hospital
Okayama, Okayama-ken, 700-0013, Japan
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Okayama University Hospital
Okayama, Okayama-ken, 700-8558, Japan
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Osaka Womens and Childrens Hospital
Izumi-shi, Osaka, 594-1101, Japan
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, 100730, China
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Perth Childrens Hospital
Nedlands, Western Australia, 6909, Australia
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Phoenix Childrens Hospital
Phoenix, Arizona, 85016, United States
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Queen Elizabeth University Hospital
Glasgow, G51 4TF, United Kingdom
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Royal Manchester Childrens Hospital
Manchester, M13 9WL, United Kingdom
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Samodzielny Publiczny Zaklad Opieki Zdrowotnej Centralny Szpital Kliniczny UMeds
Lodz, 91-738, Poland
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Semmelweis Egyetem
Budapest, 1094, Hungary
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Shandong Provincial Hospital
Jinan, Shandong, 250021, China
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Shanghai Sixth Peoples Hospital
Shanghai, 200233, China
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Sheffield Childrens Hospital
Sheffield, S10 2TH, United Kingdom
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Szpital Miejski w Tychach Spolka z ograniczona odpowiedzialnoscia
Tychy, 43-100, Poland
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The First Bethune Hospital of Jilin University
Changchun, Jilin, 130021, China
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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The University of Hong Kong-Shenzhen Hospital
Shenzhen, Guangdong, 518053, China
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Tokyo Metropolitan Children's Medical Center
Fuchu-shi, Tokyo, 183-8561, Japan
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Tongji Hospital , Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430030, China
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Tottori University Hospital
Yonago-shi, Tottori, 683-8504, Japan
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Universitaets-Kinderspital beider Basel
Basel, 4031, Switzerland
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Universitaetsklinikum Koeln
Cologne, 50937, Germany
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Universitaetsklinikum Wuerzburg
Würzburg, 97074, Germany
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Universitair Ziekenhuis Leuven - Campus Gasthuisberg
Leuven, 3000, Belgium
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University of California, Los Angeles Interventional Clinical Trials
Los Angeles, California, 90095, United States
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University of South Florida - Carol and Frank Morsani Center for Advanced Health Care
Tampa, Florida, 33606, United States
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Vanderbilt University Medical Center
Nashville, Tennessee, 37212-3157, United States
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West China Hospital Sichuan University
Chengdu, Sichuan, 610044, China