New drug aims to strengthen bones in kids with rare brittle bone disease
NCT ID NCT06636071
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 study tests setrusumab, a monthly IV infusion, in 6 Japanese children with osteogenesis imperfecta (types I, III, or IV), a condition that causes fragile bones and frequent fractures. The main goal is to see if the drug lowers the number of fractures, including spine fractures. All participants have had at least one fracture in the past year and have used or are using bisphosphonate therapy.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- setrusumab (a monoclonal antibody given by IV infusion once a month)
- What this could lead to
- If it works, this could point toward a treatment that lowers fracture rates in children with brittle bone disease.
- What could go wrong
- This is a small, open-label study with only 6 participants, so results may not apply broadly. Setrusumab may not reduce fractures as hoped, and side effects from the infusion are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Keio University Hospital
Tokyo, Japan
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Osaka Metropolitan University Hospital
Osaka, Japan
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Osaka University Hospital
Osaka, Japan
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Other studies related to the condition(s) this trial covers.
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