Bone disorder

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This trial studies a device called coflex, a small implant placed in the spine after decompression surgery for lumbar spinal stenosis (a narrowing of the spinal canal that causes back and leg pain). The study includes 40 adults with moderate to severe stenosis and low back pain. …

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This study tests a weekly injection called TransCon CNP in children aged 2 to 10 with achondroplasia, the most common form of dwarfism. The goal is to see if it can safely improve growth over one year. Half the children receive the drug and half receive a placebo, and all childre…

This study compares different exercise programs for adolescents with idiopathic scoliosis who have undergone spinal fusion surgery. Participants are divided into three groups: one doing body awareness therapy plus core stabilization, one doing core stabilization alone, and a cont…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study compares standard Schroth exercises with a virtual reality version of the same exercises in teens aged 10–15 with mild adolescent idiopathic scoliosis (curves of 10–30 degrees). The goal is to see if adding VR improves spinal alignment, trunk rotation, and mobility mor…

This study tests a new drug, AZD9829, in people with blood cancers that have come back or not responded to other treatments. The drug targets a protein called CD123 found on cancer cells. The main goals are to find a safe dose and check for side effects. About 56 adults will take…

This trial investigates whether doxercalciferol, a form of vitamin D, can prevent bone loss in the spine and thigh bone in postmenopausal women with low bone density. Participants take either doxercalciferol or a placebo daily for two years, with bone density measured at the star…

This study tests whether a mobile-friendly gamified app, called Game-App-KNEE, can improve functional outcomes and recovery for people who have had total knee replacement surgery. Participants use the app daily for three months after discharge, while a control group receives only…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study tests a drug called FT-2102 (olutasidenib) in people with acute myeloid leukemia or myelodysplastic syndrome whose cancers have a specific IDH1 gene mutation. The drug is given alone or combined with standard chemotherapy drugs (azacitidine or cytarabine). The goal is …

This study looked at whether using a soft hip brace (abduction splint) for two months in one-month-old babies with mild hip dysplasia (stable hips but abnormal ultrasound) improves hip development. 90 infants were enrolled. The goal was to see if the brace makes hip ultrasound me…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This phase III trial tests whether the drug tipifarnib can prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. Participants include adults over 60 in first remission, those in second or later remission, or those who achieved remission a…

This study tested whether injecting bevacizumab (a drug that blocks blood vessel growth) into the joints of people with hemophilia can prevent repeated bleeding episodes. Eighteen participants with chronic synovitis (joint inflammation) received the injection. Researchers measure…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study looked at adding the drug pazopanib to standard radiation or chemoradiation before surgery for patients with certain soft tissue sarcomas. The goal was to see if the combination is safe and helps shrink tumors more effectively. About 140 adults and children with newly …

This phase 3 trial is testing whether a combination of three drugs—azacitidine, venetoclax, and ATRA—can safely and effectively treat adults newly diagnosed with acute myeloid leukemia (AML). The drugs work together to stop cancer cell growth by demethylating DNA, promoting cell …

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measure…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study tested whether adding an immunotherapy drug called APX005M to standard chemotherapy (doxorubicin) could help shrink tumors in people with advanced soft tissue sarcoma. 27 adults with certain sarcoma types took part. The goal was to see if the combination was safe and w…

This early-phase trial tested a personalized cell therapy for people with advanced bone or soft tissue sarcoma that had stopped responding to standard treatment. The therapy uses the patient's own immune cells, modified to better recognize and attack cancer cells carrying a speci…

This Phase 1 study tested a single injection of SHR-3045 in 16 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Because this…

This study looked at how safe and effective peficitinib is for people with rheumatoid arthritis (RA) in everyday medical practice. About 3,000 patients who were starting peficitinib for the first time took part. Researchers tracked side effects and measured disease activity using…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta, also known as brittle bone disease. 350 participants were…

This study tested whether adding natural ingredients like garlic oil and nattokinase to standard hormone replacement therapy (HRT) could reduce the risk of blood clots in menopausal women. The trial involved 60 women divided into premenopausal and postmenopausal groups. Researche…

This study tested a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal was to see if the drug could shrink the spleen and improve blood counts. While not a cure, the treatment aims to control the disease and reduce symptoms.

This study looked at whether a program of core stabilization exercises could help teenagers who had surgery for scoliosis (a curved spine) have more balanced shoulders and shoulder blades. Twenty teens aged 10 to 18 who had spinal fusion surgery did the exercises and were tested …

This study looked at whether shining a special low-level laser on the gums after getting a dental implant can reduce swelling, pain, and help the implant stay stable. Fifty adults who needed implants took part. The laser was used right after surgery, and the team checked healing,…

This study tested a new way to set the breathing machine during back surgery. Instead of using standard settings, doctors adjusted the machine based on how stiff the patient's lungs were. The goal was to see if this approach could reduce lung problems after surgery. The study inv…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This study looked at the safety and effectiveness of a drug called asciminib in 85 Indian adults with a specific type of leukemia (Ph+ CML-CP). Some participants had a genetic mutation (T315I) that can make treatment harder, while others had already tried two or more other drugs.…

This early-phase trial tested whether adding the drug uproleselan to standard chemotherapy (cladribine and low-dose cytarabine) could help people with treated secondary acute myeloid leukemia (AML). Secondary AML is a type of leukemia that develops after treatment for another bon…

This study tested a new formulation of two chemotherapy drugs (CPX-351) in 56 adults with newly diagnosed acute myeloid leukemia (AML) who were at high risk of not responding to standard treatment. The goal was to find the best dose and see how well it worked to stop cancer cells…

This study tested whether the drug abaloparatide (Tymlos) can reduce bone loss after total knee replacement in people with osteoporosis or osteopenia. 58 participants took the drug for 18 months. The main goal was to see if bone density around the new knee improved compared to be…

This study tested a combination of three drugs (decitabine, venetoclax, and ponatinib) in 20 adults with a rare, aggressive leukemia called Philadelphia chromosome-positive acute myeloid leukemia or chronic myelogenous leukemia in blast phase. The goal was to see if the drugs cou…

This early-stage trial tested the safety of a new drug called SHR-3045 in 40 healthy adults. The study was randomized, double-blind, and placebo-controlled, meaning some participants got the drug and some got a dummy shot. The main goal was to see if the drug causes any side effe…

This study tested a new drug called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. In the first part, the drug was given alone to find the safest dose. In the second part, it was given with or without another drug (ruxolitinib) to see if it…

This study looked at how different recreational exercises—swimming, Pilates, and walking—affect muscle strength and balance in women at risk for osteoporosis. 60 women who had not exercised regularly took part. The goal was to see which activity might help prevent falls and fract…

This study tested whether adding a drug called oblimersen to standard chemotherapy (daunorubicin and cytarabine) helps older adults (60+) with untreated acute myeloid leukemia live longer or achieve remission. About 500 participants were randomly assigned to receive chemo with or…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-phase study tested a new drug called TQ05105 in 79 adults with certain blood cancers (myeloproliferative neoplasms). The main goals were to find the safest dose and understand side effects. The drug works by blocking a protein (JAK2) that can cause abnormal blood cell …

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

This study tested a new, less invasive surgery for children aged 4 to 10 with a stubborn clubfoot deformity called 'bean-shaped foot.' Instead of cutting bones, surgeons placed a small metal plate across a joint in the foot to gently guide growth and straighten the foot over time…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested a new drug called TQ05105 in 107 people with moderate to high-risk myelofibrosis, a rare bone marrow disorder that often causes an enlarged spleen. The goal was to see if TQ05105 could shrink the spleen better than the standard drug hydroxyurea. Participants too…

This large phase III trial tested whether adding the drugs bortezomib and sorafenib to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) live longer without the cancer returning. Over 1,600 participants took part. The study focused on patients w…

This Phase 3 study tested guselkumab, a drug given by injection, in 741 adults with active psoriatic arthritis. The goal was to see if it reduces joint pain and swelling. Participants received either guselkumab or a placebo. The main measure was a 20% improvement in arthritis sym…

This phase 2 trial tested a combination of intravenous busulfan, etoposide, and low-dose total-body irradiation before a donor stem cell or bone marrow transplant in 30 patients with advanced leukemia or myelodysplastic syndromes. The goal was to see how well this regimen control…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This study tested a surgical technique called a dermal roll flap to support the nostril base in 45 people who had a previous cleft lip repair. The flap uses extra skin from the lip to lift and stabilize the nostril on the cleft side. Researchers measured changes in nostril positi…

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This study tested a new treatment for adults with a high-risk form of acute promyelocytic leukemia (APL). The experimental therapy combined arsenic trioxide, ATRA, and a low dose of idarubicin, aiming to improve survival and reduce side effects compared to the standard chemothera…

This phase 2 trial tested whether certain biomarkers in bone marrow can predict how well patients with high-risk acute myeloid leukemia (AML) respond to treatment with sirolimus plus standard chemotherapy (MEC). The study enrolled 39 adults with AML that was hard to treat or had …

This study looked at whether giving tranexamic acid (a medicine that reduces bleeding) both through an IV and directly into the hip joint during hip replacement surgery can safely lower blood loss. 58 adults having elective hip replacement took part. The goal was to see if the co…

This study tested whether combining a Mediterranean diet with progressive resistance training could improve bone density in adults aged 65 and older. Over 12 months, 22 participants followed the diet and exercise program, while 19 received no structured intervention. Researchers …

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. Participants took the drug by mouth once a week for a year to see if it was safe and co…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This phase 2 trial tests whether a combination of clofarabine and intermediate-dose cytarabine (CLARA) works better than high-dose cytarabine (HDAC) alone as consolidation therapy for younger adults (18-60) with newly diagnosed acute myeloid leukemia (AML). After initial remissio…

This study looked at 31 adults with chronic myeloid leukemia (CML) whose cancer came back after they stopped taking imatinib. They were given nilotinib, a more powerful targeted therapy, to see if it could make their cancer undetectable again and allow them to stop treatment once…

This pilot study tested a surgical technique using donor tissue without metal implants to treat recurrent shoulder dislocation with bone loss. Twenty participants were followed for 24 months to measure arm function and safety. The goal was to see if this approach can stabilize th…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. The goal was to see if it reduces joint swelling and pain better than a placebo. The trial is complete, and results will help decide if further testing is wa…

This study looked at whether adding virtual reality games to standard scoliosis exercises helps teenagers with curved spines. Twenty teens aged 10-15 with moderate scoliosis took part. Half did regular exercises, and the other half also played virtual reality games for balance an…

This study tested a three-drug combination (navitoclax, venetoclax, and decitabine) in 6 adults with high-risk myelodysplastic syndrome (MDS) that came back or didn't respond to standard therapy. The goal was to find the safest dose and see if the combo could shrink or control th…

This study looked at whether adding focused radiation (SBRT) or surgery to standard treatments like chemo or hormone therapy helps people with breast cancer that has spread to just one or two places. 129 participants were randomly assigned to get standard care alone or standard c…

This early-phase study tested a combination of three chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in children whose acute myeloid leukemia (AML) had come back or didn't respond to standard treatment. The main goals were to find the best dose and check for side effects. …

This study looked at whether taking NSAIDs every day, instead of only when needed, can prevent spine damage in people with ankylosing spondylitis who are also receiving anti-TNF therapy. 188 adults participated in this Phase 3 trial. The goal was to see if continuous NSAID use re…

This study looked at 220 adults with chronic myeloid leukemia who had been in deep remission for at least two years while taking imatinib. Researchers wanted to see if stopping the drug would cause the cancer to come back. They found that many patients stayed in remission after s…

This early-phase study tested a new drug called TGR-1202 combined with the standard drug ruxolitinib in 60 people with myelofibrosis or polycythemia vera. The goal was to see if the combination is safe and tolerable. Participants either had not responded well to ruxolitinib alone…

This study tested a new standing therapy device with a biofeedback mechanism in 32 children and adolescents aged 8-16 with idiopathic scoliosis. Participants used the device or received other therapies twice a week for six months. The main goal was to see if the device could redu…

This study looked at 351 people with knee arthritis and a torn meniscus to see if surgery or physical therapy works better. Participants were randomly assigned to have knee surgery or follow a physical therapy program. The main goal was to measure changes in knee function and pai…

This study tested a new drug called S65487, which blocks a protein that helps leukemia cells survive, combined with the standard drug azacitidine. The trial included 57 adults with untreated acute myeloid leukemia who were not healthy enough for intensive chemotherapy. Researcher…

This study tested a new clinic that sees emergency room patients the next day for conditions like pneumonia, heart failure, and kidney injury. The goal was to avoid hospital stays and improve patient care. About 570 adults took part, and researchers measured how many days they we…

This study compared two types of total knee replacements in 160 patients with medial knee arthritis. One group received a fixed-bearing implant, the other a mobile-bearing implant. Researchers measured knee function and X-ray results to see if one design leads to better outcomes.

This study tested whether a procedure called Subchondroplasty, which fills bone defects with a special material, plus standard knee arthroscopy works better than arthroscopy alone for treating bone marrow lesions in the knee. About 131 adults with knee pain and osteoarthritis too…

This study looked at 60 adults with degenerative spondylolisthesis, a condition where a spine bone slips forward causing pain. All patients needed spinal fusion surgery. The researchers compared two surgical methods: one that fuses the back of the spine only, and another that als…

This early-phase study tested whether adding two targeted drugs, gemtuzumab ozogamicin and midostaurin, to standard chemotherapy is safe for people with a newly diagnosed, aggressive form of acute myeloid leukemia (AML) that has a FLT3 mutation. The trial enrolled 21 adults and a…

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This phase 1 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 29 patients whose acute myeloid leukemia or myelodysplastic syndrome came back or did not respond after a donor stem cell transplant. The goal was to find the safest dose and see if the drugs could he…

This phase 2 trial tested sodium valproate, a drug used for seizures, in 41 children with Rubinstein-Taybi syndrome (RTS), a rare genetic condition causing intellectual disability. Participants aged 6 to 21 received either the drug or a placebo for one year. Researchers measured …

This study tested a combination of three drugs (low-dose cytarabine or azacitidine, plus venetoclax and quizartinib) in 113 adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who were not eligible for standard chemotherapy. The goal was to quickly control …

This study looked at whether using a robotic system (ROSA) during knee replacement surgery leads to more accurate implant placement compared to traditional methods. It included 252 adults with knee pain, arthritis, or deformities who were already scheduled for knee replacement. R…

This study tested a plastic meniscus implant in 115 adults aged 30-75 who still had knee pain after having part of their meniscus removed. The goal was to see if the implant is safe and helps reduce pain and improve knee function. Participants were followed for up to 5 years afte…

This study tested the drug filgotinib (Jyseleca) in 118 Korean adults with rheumatoid arthritis. The goal was to see how many patients experienced at least a 20% improvement in symptoms after 12 weeks of treatment. The trial is complete, and results will help determine if filgoti…

This study tested a new, simple device to reduce the size of wide gaps in the jawbone (alveolar clefts) in 15 people aged 12-25 with repaired cleft lip and/or palate. The device slowly pulls the bone together before a bone graft, aiming to make the graft more successful. The stud…

This early-phase study tested a new drug called siremadlin added to two existing drugs (venetoclax and azacitidine) for adults with acute myeloid leukemia (AML) who are too frail for standard chemotherapy. The study included 14 people whose cancer did not respond well to initial …

This study tested whether giving only calcitriol (a form of vitamin D) to 16 children and adults with X-linked hypophosphatemia (XLH) could raise blood phosphate levels and improve bone growth without causing kidney stones. Participants took increasing doses of calcitriol for one…

This phase 2 study tested an oral drug called bomedemstat in 20 adults with polycythemia vera, a rare blood cancer that causes too many red blood cells. The main goal was to see if the drug could safely lower red blood cell levels enough to avoid routine blood removal (phlebotomy…

This early-stage trial tested a new injection for wrist osteoarthritis that combines the patient's own fat (microfat) and platelet-rich plasma (PRP). The goal was to see if this mixture is safe and can reduce pain and improve wrist function, potentially delaying the need for surg…

This study tested a new calcium phosphate putty to repair bone gaps in the gums of 84 children with unilateral cleft lip and palate. The putty was compared to the standard approach of using the child's own bone. Researchers measured how much bone remained after one year, as well …

This study tested an experimental pill called Bomedemstat in 73 people with essential thrombocythemia, a rare blood condition causing too many platelets. Participants had already tried at least one standard treatment without success. The main goals were to check safety and see if…

This study tested whether an oral medication (CC-486) could help elderly patients with a serious blood disorder called myelodysplastic syndrome (MDS) maintain their improvement after initial injectable treatment. Eleven patients who had responded to injectable azacitidine switche…

This early-stage study tested a new drug called LYT-200 in 101 adults whose acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) had come back or stopped responding to treatment. The main goals were to check the drug's safety and find the right dose. While not…

This study tested whether membranes made from a patient's own blood (L-PRF) can seal the skull base after sinus surgery as well as standard fibrin glues. 220 adults with sellar lesions were randomly assigned to receive either L-PRF or commercial sealants. The main goal was to com…

This early-phase trial tested a combination of two drugs, enasidenib and cobimetinib, in just 3 patients with a specific form of acute myeloid leukemia (AML) that had come back or didn't respond to treatment. The goal was to see if the combination was safe and to find the best do…

This Phase 3 trial tested a single injection of TG-C, a cell-based treatment, in 531 people with moderate knee osteoarthritis. The goal was to see if it reduces pain and improves knee function compared to a placebo injection. Participants were followed for 24 months to check safe…

This study looked at two osteoporosis medications—romosozumab and denosumab—in 54 people who take long-term steroids and have weak bones. Participants first received either romosozumab for 12 months followed by denosumab, or denosumab alone for 24 months. Then everyone stayed on …

This study tested a triple therapy—surgery, stem cells, and hyperbaric oxygen—in 24 patients with early-stage osteonecrosis (bone death) of the hip. After two years, patients reported better hip function and fewer needed a hip replacement. The approach aims to stop the bone from …

This phase 3 trial tested whether adding paroxetine, an antidepressant, to standard methotrexate therapy can better control rheumatoid arthritis. 100 adults with active RA took part. The main goal was to see if the combination lowers disease activity scores more than methotrexate…

This early-stage trial tested an oral drug called NTX-301 in 22 adults with certain blood cancers (MDS, AML, or CMML) that had not responded to prior treatments. The main goal was to check safety and find the right dose. Researchers also looked for signs that the drug might help …

This study followed 77 adults who received spinal implants (PASS LP, PASS DEGEN, or PASS TULIP PRIME) to treat degenerative spine conditions like disc degeneration or spinal deformity. The main goal was to see if the bones fused properly after 24 months. Researchers also tracked …

This study tested different drug combinations to prevent graft-versus-host disease (GVHD) in 174 people with blood cancers receiving stem cells from an unrelated donor. GVHD is a serious side effect where donor cells attack the patient's body. The goal was to find which drug regi…

This study tested whether a personalized surgical guide (TOKA) helps surgeons correct knee alignment more accurately than standard tools. 56 adults with medial knee osteoarthritis took part. The goal was to see if the custom approach leads to better bone alignment after surgery, …

This study compared four different knee replacement devices in 218 adults with knee arthritis to see which one patients 'forget' about most after surgery. The main goal was to measure how natural the joint feels using the Forgotten Joint Score. Results could help surgeons choose …

This study tracked over 2,300 adults in Korea who were prescribed Skyrizi (risankizumab) for moderate to severe plaque psoriasis or psoriatic arthritis. Researchers monitored side effects and symptom changes for 52 weeks during routine doctor visits. The goal was to confirm the d…

This study tested whether specialized scoliosis exercises (PSSE-Schroth) are better than general strengthening exercises for teenagers with mild idiopathic scoliosis. Over 12 months, researchers measured changes in spine curvature and how many kids needed a brace. The goal is to …

This study tested a new way to rebuild the lower jaw after removing benign tumors. Surgeons used virtual 3D planning to create custom-made plates and combined them with a piece of the patient's own rib bone. Thirty people took part, and the team checked how well the wounds healed…

This study tested a new medicine called AOC 1020 in 90 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. The goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a p…

This study tested a new approach for children and adults whose acute myeloid leukemia (AML) came back after a stem cell transplant. Researchers gave patients a special type of immune cell called cytokine-induced memory-like natural killer (CIML NK) cells, along with donor immune …

This phase 2 trial tested whether adding asciminib to the standard drug imatinib helps people with chronic myeloid leukemia (CML) achieve deeper remission. 104 adults who had been on imatinib for at least a year without reaching very low cancer levels were randomly assigned to ad…

This study followed 77 people who had a procedure called Subchondroplasty for hip bone defects. Doctors injected a calcium phosphate bone filler into the damaged area. The goal was to see if it improved pain, movement, and daily activities over two years. Results were measured us…

This early-phase study tested a two-drug combination (pevonedistat plus decitabine) in 12 people with high-risk acute myeloid leukemia (AML), including those who had relapsed or couldn't tolerate standard chemo. The main goal was to find the safest dose and identify side effects.…

This study looked at how well a special knee replacement (MUTARS) works after removing bone cancer. Nine patients were checked to see if they could lock their new knee and walk actively. The goal was to understand if the prosthesis helps with daily movement and walking.

This study looked at 45 people with osteoporosis caused by long-term steroid use. Participants had stopped taking denosumab and were switched to either zoledronic acid or alendronate at different times. The goal was to see which timing and drug best controlled bone loss markers. …

This study tested a new 3D bone scan camera (VERITON-CT) that takes only 25 minutes and uses less radiation than standard scans. Researchers compared it to conventional 2D scans in 146 people with suspected or known bone metastases. The goal was to see if the new method could acc…

This study tested a new structured reporting system called BTI-RADS to help doctors better assess bone tumors from X-rays, CT, and MRI scans. Researchers analyzed images from 1,100 patients to see if the tool could more accurately tell which tumors are likely cancerous. The goal …

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This study looked at tiny molecules in the blood, called microRNAs, to see if they can help diagnose adolescent idiopathic scoliosis (AIS), a condition that causes a curved spine in teens. Researchers compared blood samples from 20 teens with AIS and 10 healthy teens to find diff…

This study tested whether a self-assessment questionnaire for the shoulder, knee, or ankle can help people decide if they need an orthopedic specialist visit. 150 adults who already requested an orthopedic exam filled out the questionnaire. Researchers will analyze the answers to…

This study tested two 8-week exercise programs in 45 amateur padel players to see if they could reduce risk factors for lateral epicondylitis (tennis elbow). Both programs involved strength exercises for the forearm and shoulder. The goal was to improve wrist, grip, and rotator c…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study looked at whether nasal drops made from Pistacia lentiscus oil (a natural plant oil) can help prevent chronic sinusitis from coming back. 100 adults with frequent sinus infections were followed for 12 months. One group used the oil drops plus a saltwater rinse, while t…

This study looked at whether taking resveratrol (a natural compound found in grapes and red wine) every day could help prevent bone loss in postmenopausal women with low bone mass. 52 women who were 1 to 10 years past menopause took part. Researchers measured bone health through …

This study tested whether a special sitting position that centers the hip joint can prevent hip dislocation in children with severe cerebral palsy. Seventeen children aged 1-6 years participated, using either the experimental or usual sitting method for at least 5 hours daily ove…

This study tested whether atenolol, a widely used beta blocker for heart conditions, can prevent bone loss in postmenopausal women. 420 healthy women aged 50-75 took either atenolol or a placebo daily for a period. The main goal was to see if the drug slowed bone density loss in …

This pilot study tested whether a one-day Acceptance and Commitment Therapy (ACT) workshop, plus a follow-up phone call, could help prevent chronic pain after back surgery. 45 adults scheduled for spinal surgery took part. The study focused on whether the workshop was acceptable …

This study tested a procedure called Periodontally Accelerated Osteogenic Orthodontics (PAOO) in 20 adults getting braces. The goal was to see if it could prevent bone loss and gum recession on the front of the lower teeth. The procedure combines a small cut in the gum with a bon…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study investigates whether adding dance-based exercises to standard scoliosis therapy improves physical fitness, body image, and quality of life in adolescents with mild scoliosis. Twenty-four teens aged 10–18 with a spinal curve between 10 and 30 degrees will be randomly as…

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This study tests whether adding shock wave therapy to a specific trigger point in the forearm muscle can improve grip strength and reduce pain in people with tennis elbow. Fifty-two adults with tennis elbow will receive standard shock wave treatment to the elbow, plus either real…

This study compares two types of Pilates—one done in water and one on a mat—to see which better improves breathing, mobility, and quality of life in older women with a curved upper spine (kyphosis). Forty women aged 55 to 65 with mild to moderate kyphosis will follow a 12-week pr…

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study looked at whether scoliosis-specific corrective exercises, like the Schroth method, can improve physical fitness in teens with idiopathic scoliosis. Forty-two adolescents aged 10 to 19 with mild to moderate curves took part. They did either supervised exercises twice a…

This study tested two acupuncture methods—thread-embedding and electroacupuncture—in 60 adults with knee osteoarthritis. Participants received 4 weeks of treatment plus standard care. The goal was to see which approach better reduced pain and improved knee function. Results may h…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested whether a special nerve block given during cleft palate repair can lower pain and reduce the need for opioids in children. Forty children having their first cleft palate surgery received the nerve block. Researchers measured pain scores and opioid use to see if …

This study tested whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy helps people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months took part. The breathing therapy involved short cy…

This study tested whether a higher concentration of ozone injected into the knee works better than a lower concentration for treating osteoarthritis. 159 patients received one of two ozone strengths and were followed for 3 months. Researchers measured pain, stiffness, and daily f…

This study tested a dietary supplement called INTOFINE-JOINT SUPPORT in 33 adults aged 40-60 with mild knee osteoarthritis. Participants took the supplement for 60 days, and researchers measured changes in pain, stiffness, and physical function using standard questionnaires and t…

This study tested a one-year support program (JASP-1) for children newly diagnosed with juvenile idiopathic arthritis (JIA). The program included seven structured visits with a focus on the child and family. Researchers compared registry data from 56 children who took part in the…

This study compares two treatments for knee osteoarthritis: a nerve block injection guided by ultrasound and standard physical therapy. Researchers want to see which method better reduces pain, improves mobility, and helps balance. The study will include 66 adults aged 40-70 with…

This study tested whether a gentle electrical current, called frequency specific microcurrent, can lower inflammation and pain in obese adults with osteoarthritis. Ten participants received one hour of treatment and had blood drawn to measure inflammatory markers. They also fille…

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to ma…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This study tested two different exercise approaches in 34 people aged 11–24 with idiopathic scoliosis and chronic low back pain. Researchers measured changes in back muscle tissue thickness, pain levels, and daily function. The goal was to see which exercise method works better f…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This study tested two treatments for Golfer's Elbow, a painful elbow condition. Twenty-nine adults received either dry needling (thin needles into trigger points) or neural mobilization (gentle nerve stretches). Researchers measured pain, grip strength, and movement range to see …

This pilot study tested whether village doctors in rural China can effectively deliver an exercise program for people with knee osteoarthritis. Sixteen participants either received supervised exercise three times a week for 12 weeks followed by independent exercise, or usual care…

This study compared two treatments for plantar fasciitis, a common cause of heel pain: shock wave therapy and whole body vibration. Sixty adults with heel pain for at least 4 weeks were randomly assigned to one of the treatments. The goal was to see which better reduces pain and …

This study tested two physical therapy methods—Mobilization with Movement and Cyriax techniques—in 56 athletes with tennis elbow. Participants received treatment five times a week for four weeks. Researchers measured pain, grip strength, and joint position sense to see which meth…

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This pilot study tested whether a special cushion called Dasuit can reduce low back pain and improve posture in 20 adults with sitting-related discomfort. Participants sat on either the Dasuit cushion or a placebo cushion for 10 minutes while pressure and spinal alignment were me…

This study tested whether a new prosthetic hand, the SoftHand Pro, helps people with below-elbow limb loss perform daily activities better than a commonly used hand, the i-Limb. Thirty-six adults who already use a myoelectric hand took part over 8 weeks. Researchers measured how …

This study tested three treatments—shockwave therapy, high-power laser, and platelet-rich plasma injections—in 96 people with heel spurs. The goal was to see which one best reduces pain and improves daily function. Participants were randomly assigned to one of the treatments, and…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study looked at 60 people having total knee replacement surgery to see which of two nerve blocks works better for pain control when added to a standard block. One block targets the space behind the knee (IPACK), the other targets a muscle plane (AMM). The goal was to reduce …

This study tested whether a device that gently stimulates the vagus nerve through the ear could help control rheumatoid arthritis in one patient who had their spleen removed. The patient used the device at home for 24 months and visited the clinic every two months for checkups. T…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This study tested whether a numbing injection behind the nose (sphenopalatine ganglion block) could reduce confusion and agitation after sinus surgery. 100 adults received either the nerve block or a placebo. The goal was to see if the block helped patients wake up more calmly an…

This study looked at whether a lumbar epidural steroid injection can reduce restless legs syndrome symptoms in 45 adults with lumbar central spinal stenosis. Participants received a standard injection as part of routine care, and their restless legs severity, pain, disability, an…

This study tested whether giving teens extra doses of the steroid dexamethasone after scoliosis surgery could reduce inflammation, pain, nausea, and hospital stay. Forty-two adolescents with scoliosis were randomly assigned to receive either one standard dose or three extra doses…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested a minimally invasive surgery for people with kneecap pain, dislocation, or instability. Surgeons used their finger to guide a small cut to release tight ligaments, aiming for less tissue damage than open surgery. 23 participants were enrolled. The approach may r…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study looked at 20 people with severe hip arthritis who needed a hip replacement. They were randomly assigned to get either a short or a long stem implant. Researchers used 3D motion capture to measure walking patterns before surgery and at several points after, to see if on…

This study tested whether using a blue laser before a standard red laser can help reduce muscle and joint pain in 44 adults with chronic neck or shoulder pain. Participants received a 13-minute treatment combining both lasers. The goal was to see if at least 65% of people got a 3…

This study tested three treatments for tennis elbow (lateral epicondylitis) in 27 adults over 6 weeks: blood flow restriction exercise with light weights, eccentric exercise with heavier weights, or wearing a wrist brace alone. The goal was to see which approach best reduces pain…

This study tested whether rinsing the sinuses with hot saline (50°C) during surgery for chronic sinusitis reduces bleeding and improves the surgeon's view. 59 adults were split into three groups: hot saline, room-temperature saline, or no rinse. The goal was to see if the hot rin…

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch co…

This study compared two treatments for tennis elbow (lateral epicondylitis): shock wave therapy and a single injection of 5% dextrose (sugar water). 96 adults with persistent pain for at least 3 months were split into three groups: standard care alone, standard care plus shock wa…

This study tested whether a personalized, supervised home exercise program helps people recover better after total hip replacement compared to just receiving an exercise brochure. 44 people who had hip replacement surgery were split into two groups: one got a tailored exercise pl…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This study tested whether a J-shaped skin incision, instead of the usual straight cut, can reduce numbness and pain after total knee replacement. Sixty-two patients with severe knee arthritis were randomly assigned to get either the standard or the J-shaped incision. The research…

This study looked at whether using a forced-air warming blanket during knee replacement surgery helps prevent hypothermia (low body temperature) and related problems like shivering. Researchers compared 240 patients who either got the warming blanket or standard care. The goal wa…

This study tested whether hip surgery (PAO) followed by exercise is better than exercise alone for reducing pain in adults with hip dysplasia. 69 people aged 18-45 took part. The main goal was to see which approach improved hip pain and function more after 12 months.

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This study compared two therapies—myofeedback and neuromuscular electrical stimulation—to see which better improves arm and hand function in children aged 6 to 14 who have one-sided weakness (hemiplegia) after brain tumor surgery. Forty-five children participated, and researchers…

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This study tested two physical therapy techniques—nerve flossing and deep neck flexor strengthening—in 62 adults with cervical spinal stenosis. The goal was to see which method better reduces pain, improves neck movement, and helps with daily activities. Participants did their as…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and o…

This study compared two minimally invasive procedures for knee osteoarthritis pain: genicular nerve radiofrequency ablation and intra-articular pulsed radiofrequency. Both use radiofrequency energy to reduce pain, but in different ways. Researchers enrolled 34 adults with knee os…

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested whether combining two physical therapy techniques—muscle energy technique and Mulligan mobilization—works better than standard therapy alone for tennis elbow. Forty adults with elbow pain for at least 6 weeks took part. The goal was to reduce pain and improve da…

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…

This study looked at 52 adults with EGPA (a rare inflammatory disease) and severe chronic sinusitis with nasal polyps. They received mepolizumab 300 mg every 4 weeks. The goal was to see if the drug reduces polyp size and improves symptoms like nasal congestion and sense of smell…

This study tested two physical therapy approaches for people with painful heel spurs. 38 adults received either myofascial release alone or myofascial release plus taping over several weeks. The goal was to see which method better reduces pain and improves foot function. Results …

This completed study tested two different physical therapy programs in 84 adults aged 40-60 with grade II knee osteoarthritis. One group received the Macquarie injury management protocol (soft tissue work plus exercises), while the other did a targeted knee exercise program. Rese…

This study compares two common surgeries for thumb arthritis: total joint replacement (arthroplasty) and trapeziectomy (removing a small bone). Researchers will analyze data from 1,000 patients aged 45 and older in a Swedish registry, tracking pain, function, and complications fo…

This study tested two ways of applying radial pressure wave therapy to the knee in 82 people with knee osteoarthritis. The goal was to see if targeting specific joint lines works better than treating the most painful spots. Participants received three sessions and were followed f…

This study tested whether injecting a steroid (betamethasone) directly into the torn meniscus of the knee provides better pain relief and function than the standard injection into the joint space. 70 people with stable degenerative meniscal tears were randomly assigned to one of …

This study tested two drugs, dexmedetomidine and nitroglycerin, to see which one better reduces bleeding during functional endoscopic sinus surgery (FESS). 66 adults having elective FESS were randomly assigned to receive one of the drugs to lower blood pressure and improve the su…

This study tested a dental paste called Alveogyl in 120 people who developed a dry socket after a tooth extraction. The paste is placed into the socket by a dentist to relieve pain and help the gum heal. Researchers measured pain levels and healing over 7 days. The trial is alrea…

This pilot study tested a combined program of hold-relax stretching and progressive exercises in 6 adolescent athletes with Osgood-Schlatter disease. The goal was to see if it could reduce knee pain and improve range of motion. Results are preliminary and need confirmation in lar…

This study tested whether a combination of two exercise methods (proprioceptive neuromuscular facilitation and spiral muscle chain training) can improve posture, spinal flexibility, and back muscle endurance in teenagers aged 13 to 18 with spinal curvature issues like scoliosis o…

This study tested whether using a computer navigation system with special pre-surgery X-rays (EOS imaging) helps surgeons place a new hip joint more accurately. 78 adults with hip osteoarthritis who needed a total hip replacement took part. The goal was to see if this technology …

This study tested whether a botulinum toxin injection (like Botox) can reduce pain in people with tennis elbow that hasn't improved after 6 months of standard care. 61 adults received either the injection or a placebo (fake injection). The main goal was to measure pain levels 3 m…

This study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) could extend pain relief after spine surgery. 90 adults undergoing lumbar spine surgery received one of the two additives or a placebo. The main goal was to se…

This study tested whether using virtual reality before or during total knee replacement surgery could help lower anxiety and improve recovery quality. 120 adults who had the surgery participated. The results showed that VR may be a simple, drug-free way to help patients feel calm…

This study tested whether holding a simple thigh muscle contraction for 5, 10, or 20 seconds best improves strength, pain, and daily function in people with knee osteoarthritis. 127 adults aged 40-65 with mild to moderate knee arthritis took part. All also received ultrasound and…

This early study tested a single injection of a new drug, LEO 158968, in 6 people having a gout flare. The goal was to see if it could reduce joint pain. The trial is complete, but results are not yet public.

This study tested whether applying antibiotics directly into the tooth socket after wisdom tooth removal works as well as taking antibiotic pills. 90 adults having their lower wisdom teeth taken out were split into two groups: one got antibiotic gel at the surgery site, the other…

This study tested whether adding video-call support to standard physical therapy helps people recover better after total knee replacement. 44 adults aged 50-75 with knee arthritis took part. The goal was to see if tele-rehab reduces pain, improves movement, and helps people get b…

This study tested a 6-week program that combines specific exercises with education to see if it improves walking ability in people with lumbar spinal stenosis and nerve-related leg pain. Fifty-one adults aged 50 and older took part. The intervention group received both exercises …

This study looked at whether adding two hands-on therapies—mobilization with movement and active release technique—to standard care can better relieve tennis elbow pain and improve arm function. 44 adults with tennis elbow for at least 6 weeks took part. They received either the …

This study tested a new, less invasive surgery for tennis elbow. 29 adults with chronic elbow pain received a water-jet procedure guided by ultrasound. Researchers measured pain and function changes over 12 months to see if the treatment helped.

This study tested whether taking oral hyaluronic acid supplements along with hyaluronic acid injections works better than injections alone for knee osteoarthritis. 44 people aged 60-75 with knee arthritis took part. The goal was to see if the combination improves pain, stiffness,…

This study looked at whether aerobic exercise and virtual reality games could improve functional capacity, activity, and participation in children aged 6-10 living in care facilities. Sixty-three children were split into groups: one did aerobic exercise, one played VR games, and …

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether a single dose of dexmedetomidine, given during surgery, can prevent severe agitation in children aged 1-7 after cleft palate repair. Sixty children were randomly assigned to receive either the drug or a placebo (saline). The main goal was to measure emer…

This study tested a gel containing diclofenac (a common pain reliever) applied once daily to the knee. 549 adults with knee osteoarthritis used either the gel or a placebo for 6 weeks. The goal was to see if the gel reduces pain and improves knee function better than a placebo.

This study tested two different nasal packs used after nose surgery to see which one patients liked better and which led to better healing. Twenty adults who had nasal surgery received either a VELNEZ or NASOPORE pack. Researchers checked for pain, bleeding, and how well the pack…

This study tested whether adding a blood flow restriction tourniquet to standard physical therapy helps people with tennis elbow (lateral epicondylitis) more than therapy alone. 41 adults participated, and researchers measured pain and function changes over 12 months. The goal wa…

This study tested whether applying a hot compress with black seed or ginger essential oil to the knees for 7 days could reduce pain and improve satisfaction in people with knee osteoarthritis. 120 adults with moderate knee OA were split into four groups: ginger oil plus heat, bla…

This pilot study tested whether adding group-based pain neuroscience education (PNE) to a community exercise program helps older women with knee osteoarthritis. Nineteen women aged 60+ were randomly assigned to 10 weeks of exercise plus PNE or exercise alone. Researchers measured…

This study compared two surgeries for severe thumb arthritis: simple removal of a small wrist bone (trapeziectomy) versus removal plus ligament reconstruction (the Weilby procedure). Sixty patients were randomly assigned to one surgery. The goal was to see which provides better p…

This study tested whether a home exercise program guided by the TRAK app could improve pain and function in people with knee osteoarthritis, compared to doing the same exercises without the app. Fifty patients over age 45 with knee pain took part. The goal was to see if telerehab…

This study tested two numbing methods for a common clubfoot procedure in infants: a needle-free jet injection that works in 1-2 minutes versus a topical cream that takes 30 minutes. Researchers measured pain using a standard scale, heart rate, and oxygen levels in 107 babies. The…

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested whether adding a specific nerve-stretching technique to standard massage and trigger-point therapy can better relieve chronic tennis elbow. Forty-six adults with at least three months of elbow pain received either standard care alone or standard care plus radial…

This study tested whether a short behavioral program called Acceptance and Commitment Therapy (ACT) could reduce pain and improve function in veterans at risk for persistent pain after knee replacement. 402 veterans were randomly assigned to ACT or an attention control group. Res…

This study tested three different injections for people with painful jaw arthritis: platelet-rich plasma (PRP), hyaluronic acid, and a steroid called triamcinolone acetonide. 64 adults received one of these or a placebo saline injection. Researchers measured pain and mouth openin…

This study compared a newer, less invasive endoscopic surgery to standard open surgery for people with lumbar spinal stenosis, a condition that causes back and leg pain. 36 adults who needed surgery were randomly assigned to one of the two procedures. Researchers measured pain, w…

This study tested whether moving cupping combined with bloodletting can relieve neck pain caused by qi stagnation and blood stasis. Sixty-two adults received either the cupping-bloodletting treatment or massage. Researchers measured pain, neck movement, and quality of life to see…

This study tested a system that combines a wearable knee sensor with an exercise app to help people with knee osteoarthritis. The program provides personalized exercises and real-time feedback to ensure correct form. Thirty adults with knee osteoarthritis participated, and resear…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study tested whether low-load exercise with blood flow restriction (BFR) can reduce pain and improve function in people with tennis elbow. 58 adults with recent tennis elbow did supervised exercises twice a week for six weeks, with either real or fake BFR. Researchers measur…

This study tested whether low-dose radiation therapy can reduce pain and improve function in people with knee osteoarthritis. 114 adults aged 50-85 with moderate knee arthritis received either low-dose radiation or a sham treatment. Researchers measured pain and function improvem…

This study tested whether giving acetaminophen (Tylenol) through an IV works better than pills for pain after lumbar spine surgery. 166 adults having a specific type of back fusion surgery were randomly assigned to receive either IV or oral acetaminophen. The goal was to see if t…

This study tested whether a daily capsule combining etoricoxib and diacerein can reduce pain and improve function in adults with knee or hip osteoarthritis. Over 60 days, 123 participants took either the test combination or an active comparator (meloxicam plus diacerein). Researc…

This early study tested whether a low, non-antibiotic dose of doxycycline could help people with tennis elbow (elbow tendinopathy). The goal was to see if patients would take the medication as prescribed and if it might reduce pain and improve function. Twenty-one adults with elb…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This study looked at different rehabilitation programs for 90 adults who had back surgery for degenerative lumbar disease. The goal was to see which rehab approach best reduces nerve pain, helps patients regain function, and improves quality of life. Participants were randomly as…

This study tested whether applying cold to painful joints can reduce pain and improve quality of life in people with rheumatoid arthritis. 90 patients with active pain participated. The goal was to see if this simple, low-cost method could be a helpful addition to standard care.

This study tested whether a virtual rehabilitation program called VIVA is feasible for people with spine fractures caused by osteoporosis. The program includes weekly online sessions to help reduce pain and improve movement and quality of life. The study involved 34 participants …

This study tested different doses of melatonin (3, 5, and 10 mg) compared to a placebo in 160 adults undergoing sinus surgery. The goal was to see which dose best reduces anxiety and pain while keeping heart rate and blood pressure stable. Results could help doctors choose the ri…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested whether soaking feet in warm water for 20 minutes before pituitary tumor surgery helps patients feel less anxious and keeps vital signs stable. 100 adults were enrolled, with one group receiving the foot bath and the other standard care. Researchers measured anx…

This pilot study tested whether a 5-day sailing therapy program followed by 3 months of home-based telerehabilitation is safe and feasible for young people aged 12–30 with rare skeletal disorders. 24 participants were randomly assigned to either the sailing-plus-rehab group or a …

This early study tested a tiny dexamethasone insert placed in the tear duct of 15 children after retinal surgery or laser treatment. The goal was to see if it could safely reduce pain and eye inflammation. Researchers measured pain using a standard scale and tracked any side effe…

This study tested whether a special type of exercise called isokinetic eccentric strengthening can improve knee function and reduce pain in people with knee osteoarthritis. 40 adults with one-sided knee osteoarthritis participated. The exercises focused on strengthening the quadr…

This study tested whether adding a gentle hands-on therapy called craniosacral osteopathic treatment to standard care can improve symptoms and quality of life for people with chronic sinusitis. Fifty adults with the condition were randomly assigned to receive either standard medi…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study investigates whether a portable, affordable hand dynamometer can reliably measure trunk muscle strength in adolescents with idiopathic scoliosis. Researchers will test the device on 41 teens aged 10-18, comparing results between two evaluators and across two sessions o…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study follows up with head and neck cancer patients about 7 years after they finished radiation therapy. Researchers will check for cavities, gum disease, tooth loss, bone damage, and saliva flow. The goal is to understand the long-term dental side effects of cancer treatmen…

This study looks back at medical records from a single hospital in Scotland to see how well the drug bosutinib works and how safe it is for people with chronic myeloid leukemia (CML) in everyday practice. Researchers will track blood cell counts, genetic responses, and side effec…

This completed study examined 22 adolescents with idiopathic scoliosis to see if joint hypermobility (flexibility) and foot posture are linked to the severity of their spinal curve. Researchers measured hypermobility with the Beighton Score, foot posture with the Foot Posture Ind…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study looked at 20 teens with scoliosis (a curved spine) to see if the position of their shoulder blades is linked to how well they can use their arms. Researchers measured shoulder blade movement and arm power using simple tests like throwing a weighted ball. The goal is to…

This study examined 750 emergency patients with joint pain to find out which germs cause septic arthritis. Researchers compared standard lab cultures with a new PCR test to see which works better. The goal is to help doctors diagnose joint infections more quickly and accurately.

This study looked at 60 children aged 1 to 4 years who had surgery for developmental dysplasia of the hip. Doctors compared two ways of cutting the hip capsule: a U-shaped cut and a T-shaped cut. The goal was to see which method was faster and needed fewer stitches. The results m…

This early-phase trial tested whether adding atovaquone (a drug usually used to prevent pneumonia) to standard chemotherapy is safe and reaches effective levels in the blood. It involved 26 children and young adults (ages 1 month to 21 years) newly diagnosed with acute myeloid le…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study investigates how often people with lateral epicondylitis (tennis elbow) also have posterolateral rotatory instability, a ligament problem that causes similar pain but requires different treatment. Researchers will check the elbow's lateral collateral ligament during sc…

This study tested a new way to measure nose and lip shape in 14 infants with cleft lip and palate using 3D facial scans. Researchers compared these scans to standard photos and manual measurements to see if the digital method is accurate. The goal is to find a better, less invasi…

This completed study reviewed data from 31 patients who had knee replacement revision surgery due to aseptic loosening (the implant coming loose without infection). Researchers used a regional registry and X-ray analysis to understand the causes and economic impact. The goal was …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study compares two surgical techniques used to rebuild the jawbone so dental implants can be placed. The Split Box Technique and the Split Bone Block Technique both aim to increase bone width. Researchers looked back at records of 31 patients treated at a university dental c…

This completed pilot study aimed to estimate how common osteoporosis is in France, starting with the Alpes-Maritimes region. Researchers enrolled 800 participants who each received a bone densitometry scan. The study was observational and did not test any treatment.

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 813 people with early rheumatoid arthritis in France to see how often and why doctors prescribe TNF blockers. Researchers tracked symptoms, joint damage, and treatment success over 5 years. The goal was to learn which patients benefit most and how well doctors…

This study checked whether women over 50 who had severe osteoporotic fractures (like hip or spine breaks) were scheduled for osteoporosis treatment at Nîmes University Hospital. Researchers reviewed hospital records of 500 patients to see if treatment was planned. The goal was to…

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This study followed 813 people with early rheumatoid arthritis in France to see how often doctors prescribe TNF blockers alone (without other arthritis drugs) and how well they work. Researchers tracked symptoms, joint damage, and how long patients stayed on treatment over 5 year…

This study looked at whether French doctors follow EULAR recommendations to check heart disease risk every year in patients with rheumatoid arthritis. Over 7000 patients were included. The goal was to see how often tests like blood sugar, cholesterol, and heart scans were prescri…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study observed 30 elderly patients (over 65) who had a specific type of neck fracture (odontoid fracture) from a minor fall or low-energy injury. Researchers measured bone density, vitamin D levels, and other bone health markers to understand why these fractures happen. They…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This completed study looked at the natural course of two ultra-rare genetic disorders: GACI and ARHR2. Researchers collected medical records and blood samples from 48 affected individuals and their family members. The goal was to better understand how these diseases progress over…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This study looked at 49 people with masses in the sellar region of the brain (near the pituitary gland). Researchers compared MRI scans before surgery with the final diagnosis after surgery to see how well imaging predicts the type of tumor. The goal was to improve diagnosis and …

This study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study looked at the safety of the drug RINVOQ in over 4,200 Japanese adults with rheumatoid arthritis, a condition causing joint pain and swelling. Researchers reviewed medical records for three years to count serious infections and other side effects that happened during no…

This study compared two types of surgical retractors used during hip replacement surgery to see if one caused fewer infections. 144 patients were randomly assigned to receive either a Charnley retractor or an Alexis O-Ring retractor. The researchers took tissue samples during sur…

This study looked at bone density in 448 men with hemophilia and healthy volunteers to see how common bone loss is. Participants had a bone density scan and some gave blood samples. The goal was to understand if hemophilia itself, not just lack of activity, leads to weaker bones.

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This completed study looked at inherited disorders common in Amish and Mennonite populations. Researchers collected medical histories, blood or cheek swab samples from 157 participants to find the genes behind these conditions. They also built a computer database of family trees …

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at whether a special honey (Trigona sp.) helps heal wounds after cleft palate surgery better than a standard antibiotic dressing. Twenty-four children aged 18 months to 6.5 years participated. Researchers measured a healing marker in saliva before and after surg…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This study followed 220 adults with phenylketonuria (PKU) in France to learn how the disease affects them later in life. Researchers looked for signs of cognitive decline, neurological problems, and how the disease impacts quality of life and social integration. No new treatment …

This study looked at how teenagers with scoliosis sense and imagine their own bodies compared to healthy teens. Researchers tested touch sensitivity, left-right thinking, and body position awareness. The goal was to better understand how the brain might be involved in scoliosis, …

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This completed study looked at blood vessel cells from 30 people with primary myelofibrosis, a rare bone marrow disorder. Researchers wanted to see if these cells act like stem cells that could be the origin of the disease. By growing the cells in the lab, they aimed to understan…

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study investigates whether changes in DNA methylation—a kind of chemical switch—might cause certain rare limb malformations that appear without a family history. Researchers will compare DNA samples from 40 people with Amelia (missing two or four limbs) or Femur Fibula Ulna …

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This completed study enrolled 33 people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers used special sensors and gait analysis to measure how participants move. The goal was to identify which movement patterns are most useful for understanding…

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main go…

This study looked at how teriparatide (Forsteo), a daily injection, builds new bone in postmenopausal women with osteoporosis. Nineteen women took the drug for two years. The goal was not to test if it works, but to understand exactly how it changes bone density and turnover over…

This study looked at 40 people who had knee replacement surgery to see if the type of implant affects recovery. One group got a cruciate-retaining implant, the other a posterior-stabilized implant. Researchers measured pain, function, fear of movement, quality of life, and how mu…

This study looked at how kidney function and race/ethnicity affect the drug treosulfan in 20 patients with AML or MDS getting a stem cell transplant. The goal was to find safe doses for those with kidney problems. It was a small, early-phase study that did not test a new treatmen…

This study looked at the tiny organisms (bacteria and fungi) living in the mouth and nose of children with leukemia or those getting a bone marrow transplant. Researchers wanted to see how these germ communities change during chemotherapy. The goal was to learn more, not to test …

This study tested a device called NaviFast 6D, a miniature measuring arm used during hip replacement surgery to help surgeons check leg length and hip offset. Researchers compared measurements from the device to standard X-ray measurements in 84 adults undergoing hip replacement.…

This pilot study looked at factors that predict pain and function after total knee replacement. Researchers tested a brief mindfulness-based cognitive behavioral therapy in a small group of patients and compared them to those receiving usual care. The goal was to see if this appr…

This study looked at how often people with certain blood cancers or related conditions have an acquired deficiency of an enzyme called pyruvate kinase, which can cause anemia. Researchers took a single blood sample from 18 participants to measure enzyme activity and check for rel…

This study looked at immune cells in a non-cancerous gum growth called peripheral giant cell granuloma (PGCG) and compared them to healthy gum tissue from the same 28 patients. Researchers used special staining to count different types of immune cells. The goal was to better unde…

This pilot study tested whether a single dose of an oral ketone supplement could increase blood flow and improve brain connectivity in 15 older adults with subjective or mild cognitive decline. Participants had one 2-hour session including MRI scans and cognitive tests. The goal …

This study checks if a new balance assessment system gives consistent results in teenagers with scoliosis. Forty participants aged 12-18 with mild to moderate curves will perform balance tests twice, one week apart. The goal is to see if the tool is reliable for measuring postura…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study looked at different questionnaires that patients fill out after hip or knee surgery to see how well they measure recovery. Researchers wanted to find better ways to compare results across studies and understand what counts as a meaningful improvement for French patient…

This study looks at how radiation therapy for brain tumors like meningioma or pituitary adenoma might affect autobiographical memory—the memories of your life events. Researchers will ask 17 patients to complete memory tests one and two years after treatment. The goal is to see i…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked at whether a team-based health assessment before knee or hip replacement surgery improves quality of life and reduces healthcare costs for patients aged 65 and older with multiple chronic conditions. 157 patients were randomly assigned to receive either usual ca…

This study examined fluid from around dental implants to find biological markers linked to early bone loss. Researchers compared implants with and without early bone loss in 59 patients. They measured several proteins in the gum fluid to see if any could help explain why some imp…

This completed study from Turkey looked at how well rheumatoid arthritis patients can use their arms and hands. Researchers tested 26 patients using a pegboard and ring test for arm exercise, a hand dynamometer for grip strength, and a daily living test. The goal was to better un…

This study looked back at 621 children in Denmark who had chemotherapy for acute leukemia between 2008 and 2022. The goal was to find out how many got serious mold infections and what factors made it more likely. The results will help doctors better protect children during treatm…

This study looked at 50 adults having knee replacement surgery to see if a computer-guided tool (imageless navigation) can measure key knee angles as accurately as a CT scan. The tool creates a digital model of the knee during surgery, which could avoid the need for a preoperativ…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study tested a tool called UR-GOAL to help older patients with acute myeloid leukemia (AML), their caregivers, and their doctors communicate better and make decisions together. It involved 161 participants aged 60 and older. The goal was to see if the tool improved shared de…

This completed study looked at nearly 7,000 adults with inflammatory joint diseases like rheumatoid arthritis and psoriatic arthritis. Researchers compared two versions of a standard health survey (EQ-5D-3L and EQ-5D-5L) to see which one better measures health and quality of life…

This study looked at whether measuring drug levels and anti-drug antibodies in the blood of rheumatoid arthritis patients can help doctors make better treatment decisions. 52 patients starting adalimumab or certolizumab were randomly assigned to have their test results shared wit…

This study looked at how obesity and related metabolic changes affect bone development in 358 healthy girls aged 9-12. Researchers measured bone mass, density, and strength over two years. The goal is to understand these links to help prevent fractures and osteoporosis later in l…

This study looked at 20 people with lumbar spinal stenosis (a narrowing in the spine that can cause leg pain when walking) who were waiting for surgery. Researchers measured their walking patterns and asked about pain, function, and quality of life before and after the operation.…

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how different positions affect joint space measurements in people with knee osteoarthritis. 21 patients had MRI scans while standing and lying down, with their knees bent and straight. The goal was to understand how these positions change the distance between…

This pilot study tested whether a larger trial is possible comparing two standard surgeries for lumbar spinal stenosis with a related condition called spondylolisthesis. The two procedures are decompression alone and decompression with fusion. The study enrolled 70 surgical candi…

This study looked at DNA methylation patterns in stored samples from 90 patients with rare skeletal disorders, sarcomas, or inflammatory arthritis. The goal was to better understand these patterns and explore their potential for diagnosis and treatment. The research aimed to impr…

This study looked at blood samples from 24 people with axial spondyloarthritis (a type of inflammatory arthritis) and 12 healthy volunteers to understand how a receptor called KIR3DL2 contributes to inflammation. Researchers also tested whether a drug called IPH4102 could reduce …

This study looked at knee tissue that was removed during total knee replacement surgery in 29 patients. The goal was to learn more about how knee diseases and injuries affect bone and tissue structure, and to test new ideas for future treatments like custom implants or 3D-printed…

This study looked at how different types of shoe insoles affect knee movement and quality of life in people with knee osteoarthritis. Thirty participants were tested to see if insoles change how the knee works during walking and if any benefits are linked to these mechanical chan…

This study looked at 618 people aged 18 to 70 who had hip replacement surgery to see if they developed new low back pain afterward. Researchers tracked how many patients experienced their first episode of low back pain after the procedure. The goal was simply to observe and measu…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This completed study followed 73 adults with bone or joint infections who needed antibiotics for at least 6 weeks. Researchers tracked how often side effects occurred, how severe they were, and whether they affected quality of life. The goal was to understand why some patients st…

This completed study evaluated existing osteoporosis patient education programs in Danish municipalities. Researchers compared over 3,000 people who took part in group education sessions (covering medication, diet, and exercise) with a matched group who did not. They measured eff…

This study looked at whether drinking whey protein and doing simple home exercises for two weeks before hip replacement surgery helps people recover faster. Researchers measured blood markers, how soon patients could walk, and how long they stayed in the hospital. The goal is to …

This study looked at how being tired affects the chance of tripping and falling in adults aged 55-70 with and without knee osteoarthritis. 24 participants wore activity monitors, walked on a treadmill for 30 minutes, and did strength and balance tests before and after. Researcher…

This small pilot study tested a new way to place dental implants in the upper jaw when there is not enough bone height. Surgeons used a special drill and a tiny camera to watch the sinus membrane during the procedure. The goal was to see how often the membrane gets torn, which ca…

This study tested a school program called SocLaLola that uses a comic book to teach children aged 8-11 about pain. The goal was to see if it improves kids' understanding of pain and reduces their fear of moving. Eighty-two students from two primary schools took part. The program …

This completed study used artificial intelligence to examine electronic health records from 10,000 head and neck cancer patients. The goal was to create models that can predict the risk of cancer coming back or progressing, and to identify which patients might live longer after i…

This study looked at 40 people with knee osteoarthritis who received injections of platelet-rich plasma (PRP) made from their own blood. Researchers measured pain, function, and inflammation markers to see how PRP might help. The goal was to better understand the treatment's effe…

This study looked at 64 people with knee osteoarthritis to see how balance and leg muscle strength relate to their ability to do everyday tasks like walking, standing up from a chair, and climbing stairs. Researchers used tests like the 6-minute walk and a balance platform to mea…

This study looked at how healthy adults' bodies handle calcium from drinking water. 41 participants drank low-calcium water first, then high-calcium water, and researchers measured changes in blood and urine calcium and parathyroid hormone levels after 2.5 hours. The goal was to …

This study looked at whether certain gene variations affect how well a transplanted kidney works over time. Researchers checked 80 kidney transplant recipients for specific gene markers and measured their kidney function for up to three years. The goal was to find clues that coul…

This study tested whether a special CT scan (DECT) can better predict fracture risk in women with osteoporosis than the usual bone density test (DEXA). Seven women aged 60 or older participated. The goal was to develop a computer tool that analyzes bone structure from the scan to…

This study looked at whether hip X-rays can help doctors measure how much growing a teenager with scoliosis has left. Researchers examined 70 patients and graded the closure of the growth plate in the hip bone. The goal was to see if this method is reliable and easy to use in cli…

This study looked at whether the difference between how long it takes someone to actually perform a 'get up and walk' test versus how long they imagine it takes can predict future falls. Researchers followed 67 osteoporosis patients for a year after the tests. The goal was to see…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study tested whether changes in pupil size can reliably measure pain. Twenty adults with hip or knee arthritis received brief heat pulses while researchers recorded their pupil responses and pain ratings. The goal was to see if pupil diameter could serve as an objective pain…

This study looked at 308 people with myelodysplastic syndromes (MDS) who had a stem cell transplant. Researchers identified each patient's unique genetic mutations and then monitored those mutations in blood and bone marrow samples after transplant. The goal was to see if rising …

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study looked at 50 people who had jaw surgery to fix facial deformities. Researchers compared two surgical methods to see which one led to better nose and lip shape and less swelling after the operation. The goal was to find the technique that gives the best cosmetic results…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study tested a new way to measure heart fitness (VO2 max) in 30 people before and after hip replacement surgery. Participants wore a small chest sensor to estimate VO2 max without exercise. The goal was to see if this method can track natural recovery over 12 weeks. It is a …

This early-stage study tested the safety and tolerability of a new drug called RAB001 in 16 healthy adults. Researchers gave single and multiple injections at two dose levels to see how the body handles the drug and if it causes side effects. This is a first step before testing t…

This study explored how frailty affects people with lumbar spinal stenosis, a common age-related back condition. Researchers measured pain, balance, disability, fear of falling, and quality of life in 91 participants aged 45-80. The goal was to better understand frailty in this g…