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Gum fluid clues may explain early implant bone loss

NCT ID NCT07584759

Knowledge-focused Sponsor: Pamukkale University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examined fluid from around dental implants to find biological markers linked to early bone loss. Researchers compared implants with and without early bone loss in 59 patients. They measured several proteins in the gum fluid to see if any could help explain why some implants lose bone soon after placement. The goal was to better understand the biological processes behind this complication.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

59 people

The number who actually took part.

Started

Mar 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients who received implant treatment at the Department of Periodontology, Pamukkale University Faculty of Dentistry.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of 1 mm or more of radiographic marginal bone loss within the first 3 months after implant placement * Availability of radiographic documentation * Availability of demographic data, surgical records, and data related to the implant used * Physical condition classified as Class I and II according to the American Society of Anesthesiologists (ASA) classification * Patients with no smoking history in the last 10 years * Fixed implant-supported restorations * Screw-retained implants Exclusion Criteria: * Patients receiving and/or maintaining implant treatment at centers other than the Department of Periodontology, Pamukkale University Faculty of Dentistry * Patients with incomplete or unreachable files or radiographic documentation * Patients with a known systemic disease/condition that alters their physical condition or bone metabolism * Severe bruxism cases * Pregnant and breastfeeding patients * Patients with incomplete implant-supported prosthesis * Areas grafted during or before implant surgery * Removable implant-supported restorations * Cement-retained implants * Patients undergoing peri-implantitis treatment

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Conditions

The condition(s) this trial relates to.

sclerosteosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Marginal bone loss Peri implant bone loss Peri-implant health Peri-implant marginal bone loss

Contacts and locations

Locations

  • Pamukkale University, Faculty of Dentistry, Periodontology

    Denizli, 20160, Turkey (Türkiye)

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