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Could a diabetes drug help dental implants fuse better?

NCT ID NCT07770087

Disease control Sponsor: Al-Azhar University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 18, 2026 · Last updated Aug 19, 2026 · Updated 1 time

Summary

This trial asks whether applying a 1% metformin gel directly around a dental implant at the time of placement can improve bone healing. Participants are adults needing immediate implants in the upper back jaw, and the gel is used alongside a standard bone-grafting procedure. The study compares bone density and bone levels around the implant between those receiving the gel and those who do not, using 3D X-ray imaging over six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A 1% metformin gel applied topically around the dental implant at the time of placement, combined with guided bone regeneration.
What this could lead to
If effective, this could offer a simple, low-cost way to enhance bone healing around dental implants, potentially reducing implant failure and improving long-term outcomes.
What could go wrong
This is a very small early-stage trial (12 participants), so results may not apply broadly. The gel's benefit over standard care is unproven, and any improvement in bone density may not translate to better implant survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Nov 2022

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1\. All patients were free from any systemic diseases according to criteria of Cornell Medical Index and its modification(184). 2\. Patent's age at least 18 years old. 3. Patients had remaining roots or badly decayed hopeless teeth indicated for extraction for immediate implant placement in the posterior maxilla region. 4\. Extraction socket has sufficient bone quality and quantity amenable for implant length that is not less than 10 mm and of suitable diameter. 5\. The implant recipient site should be free from any pathological conditions. 6. Patients with Good Oral Hygiene, and instructed for oral hygiene measures Exclusion Criteria: * Patients with bad oral hygiene. 2. Uncontrolled systemic diseases that complicate bone healing. 3. Presence of any pathology in the implant site. 4. Heavy smokers, alcohol or drug abuse patients. 5. Patients with para functional habits such as bruxism and clenching. 6. Conditions that might lead to alteration of bone region as osteoporosis or Paget's disease. 7\. Any medicines such as bisphosphonates or steroids that affect bone turn over. 8\. History of chemotherapy or radiotherapy.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone healing Crestal bone loss Guided bone regeneration Metformin gel Peri implant bone loss

Contacts and locations

Locations

  • Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University, Assiut Branch

    Asyut, Egypt

  • Faculty of Dental Medicine, Al-Azhar University, Assiut Branch

    Asyut, Assiut Governorate, 71511, Egypt

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