Can a sedative calm the Body's stress response during brain tumor surgery?
NCT ID NCT05005715
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether giving the sedative dexmedetomidine during pituitary tumor surgery can dampen the body's stress response and improve early recovery. About 64 adults with non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery will be randomly assigned to receive either dexmedetomidine or a placebo (saline) intravenously during the procedure. Researchers will measure recovery quality using a standard questionnaire and track hormone levels related to stress.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dexmedetomidine, a sedative drug given intravenously during surgery
- What this could lead to
- If it works, this could point toward a way to help patients recover more comfortably after pituitary tumor surgery.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. Dexmedetomidine can cause low blood pressure or slow heart rate.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Seoul National University Hospital
Seoul, Seoul, South Korea
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