Can a sedative calm the Body's stress response during brain tumor surgery?
NCT ID NCT05005715
First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether giving the sedative dexmedetomidine during pituitary tumor surgery can dampen the body's stress response and improve early recovery. About 64 adults with non-functioning pituitary adenomas undergoing endoscopic transsphenoidal surgery will be randomly assigned to receive either dexmedetomidine or a placebo (saline) intravenously during the procedure. Researchers will measure recovery quality using a standard questionnaire and track hormone levels related to stress.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- dexmedetomidine, a sedative drug given intravenously during surgery
- What this could lead to
- If it works, this could point toward a way to help patients recover more comfortably after pituitary tumor surgery.
- What could go wrong
- This is a small, early-phase trial, so results may not apply broadly. Dexmedetomidine can cause low blood pressure or slow heart rate.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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64 people
The number who actually took part.
- Started
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Aug 2021
- Finished
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Apr 2023
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Non-functioning patients undergoing endoscopic transsphenoidal tumor surgery under general anesthesia Exclusion Criteria: * Patients who do not agree to participate in the study * Patients with contraindication to dexmedetomidine * Patients with previous history of endoscopic transsphenoidal tumor surgery * Patients who take anticoagulants or have bleeding disorder * Patients with conduction block or cardiovascular disease * Patients with psychiatric disease such as dementia, delirium * Patients have difficulty filling out the QoR-15 questionnaire * Pregnant or lactating women * Patients who have allergies to propofol, remifentanil, fentanyl or rocuronium * Patients with myasthenia gravis or myasthenic syndrome
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Seoul National University Hospital
Seoul, Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.