Could a common drug replace surgery for pituitary tumors?
NCT ID NCT02288962
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether cabergoline, a drug already used for hormone-producing pituitary tumors, can shrink or slow the growth of non-functioning pituitary adenomas (NFPAs). These tumors do not produce excess hormones, so current treatment is limited to surgery or radiation, which carry risks. The study enrolls adults with untreated or residual NFPAs and measures tumor volume changes over two years using MRI scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cabergoline, a dopamine agonist drug
- What this could lead to
- If effective, cabergoline could become the first drug treatment for non-functioning pituitary adenomas, reducing the need for repeated surgeries or radiation.
- What could go wrong
- This is a small phase 3 trial with 60 participants, and previous evidence is limited to non-randomized studies. Cabergoline may not shrink tumors in all patients and carries a risk of heart valve problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Department of Endocrinology, Akershus University hospital
Oslo, Norway
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Department of Endocrinology, St. Olavs Hospital
Trondheim, 7006, Norway
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Sahlgrenska University Hospital
Gothenburg, Sweden
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