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New camera modes could sharpen Colonoscopy's eye for precancerous polyps

NCT ID NCT07797361

Diagnosis Sponsor: Alexandre Vontobel Padoin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

This trial tests two new imaging modes, VIST and SFI, during colonoscopy to see if they help doctors find and classify colorectal polyps better than standard white light. About 990 adults undergoing screening or surveillance colonoscopy will be randomly assigned to one of the three imaging modes. The study compares how many polyps each mode detects, especially adenomas and serrated lesions, using tissue analysis as the reference standard. If successful, these modes could improve early detection of precancerous growths.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Colonoscopy using Versatile Intelligent Staining Technology (VIST) or Spectral Flexible Imaging (SFI), compared with standard high-definition white light endoscopy
What this could lead to
If these imaging modes work, they could help doctors find and classify colorectal polyps more accurately during routine colonoscopy, potentially improving early detection of precancerous lesions.
What could go wrong
This is an early-stage study, and the new imaging modes may not prove better than standard white light. Results depend on how well the technology performs in real-world settings and on the skill of the endoscopists.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 990 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Undergoing screening or surveillance colonoscopy * Adequate bowel preparation (Boston Bowel Preparation Scale ≥6, with ≥2 per segment) * Ability to understand and sign informed consent Exclusion Criteria: * History of inflammatory bowel disease (Crohn's disease or ulcerative colitis) * Prior colorectal resection * Colorectal stenosis preventing scope progression * Pregnancy or breastfeeding * Inadequate bowel preparation * Clinical contraindication to colonoscopy

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Conditions

The condition(s) this trial relates to.

adenoma colorectal neoplasm polyp of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adenoma Colonic polyps Colorectal cancer screening Colorectal neoplasms Serrated polyps

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital São Lucas da PUCRS

    Porto Alegre, Rio Grande do Sul, 90160-090, Brazil

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