Can a Bone-Strengthening infusion given right after hip surgery prevent a second break?
NCT ID NCT05025293
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial compares giving zoledronate, a yearly intravenous bone-strengthening drug, within 5 days of hip fracture surgery versus waiting 3 months. The goal is to see if early treatment is as safe and effective at reducing bone turnover and preventing future fractures. Participants are adults over 50 who had a low-energy hip fracture and surgery within 72 hours. The study measures bone turnover markers and recovery outcomes like mobility and delirium.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Zoledronic acid (an intravenous bisphosphonate given once yearly to strengthen bones)
- What this could lead to
- If early zoledronate works as well as delayed treatment, hip fracture patients could start protecting their bones sooner, potentially reducing the risk of another fracture.
- What could go wrong
- This is a non-inferiority trial, so it may show early treatment is not as good. Risks include kidney issues, low calcium, and side effects from the infusion.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Oslo University Hospital
Oslo, Oslo, 0424, Norway
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