HIP FRACTURES

This study compares two surgeries for a common type of hip fracture in older adults: a metal nail inside the bone versus a full hip replacement. The goal is to see which approach leads to better mobility, fewer complications, and higher quality of life. About 170 people aged 65 a…

This study follows 368 adults who need a partial hip replacement (hemiarthroplasty) due to fractures, arthritis, or bone death. Researchers will check how well Corin hip devices work and how safe they are over 10 years. The goal is to see if patients can move better and have fewe…

This study looks at whether giving two doses of tranexamic acid (a drug that helps blood clot) is better than one dose at reducing blood loss and the need for blood transfusions in older adults having hip fracture surgery. The trial includes 120 people aged 65 and older. Particip…

This study looks at whether doing hip fracture surgery within 6 hours, instead of waiting longer, can reduce deaths in patients who also have a recent heart injury. About 1100 adults aged 45 and older with a hip fracture and elevated troponin (a sign of heart damage) will be rand…

This study looks at whether older adults who break a hip from a simple fall might have an undiagnosed spinal cord condition called cervical myelopathy. Researchers will check 75 patients with a physical exam and, if needed, an MRI before they leave the hospital. The goal is to fi…

This study tests a procedure called LOEP that strengthens the hip bone to prevent a second fracture in women over 65 with osteoporosis who have already broken one hip. About 2400 women will either receive the procedure or standard care and be followed for at least 5 years. The go…

This study compares a new local anesthesia technique called PENG 360° to standard spinal anesthesia for people having hip replacement surgery after a fracture. The goal is to see if the new method controls pain just as well while allowing patients to move their leg sooner. One hu…

This study compares two types of nerve blocks (PENG vs femoral) to see which provides better pain relief for people with hip fractures. About 352 adults with a hip fracture will receive one of the two blocks, depending on the month they come to the hospital. Researchers will meas…

This study tests whether remimazolam, a newer anesthesia drug, causes less confusion (delirium) after surgery than the standard drug propofol in elderly patients having hip or knee replacement. Researchers will monitor 82 participants for three days after surgery to check for del…

This study tests whether a long-acting form of the anesthetic bupivacaine, combined with regular bupivacaine, can control pain better than the standard drug ropivacaine after hip replacement. Sixty adults with hip fractures or necrosis will receive one of the two treatments via a…

This study tests whether giving elderly patients a combination of esketamine and dexmedetomidine after hip fracture surgery can improve their sleep quality. 96 patients aged 65 and older will be randomly assigned to receive either the drug combo or a placebo (saline) for 48 hours…

This study tests if freezing a specific nerve group (cryoablation of the PENG) provides better pain control 30 days after hip fracture surgery compared to the usual method (a fascia iliaca catheter). About 150 adults aged 18-85 having hip fracture repair will be enrolled. The mai…

This study compares standard pain management to a special nerve block called PENG in 70 adults having hip fracture surgery. The goal is to see if the block reduces pain, the need for extra painkillers, and helps patients get moving faster. Researchers will also check for side eff…

This study tests whether a mobile app can help patients do simple in-bed exercises after orthopedic surgery for spine, hip, or knee problems. About 100 participants will use the app or receive usual care. Researchers will measure how well patients recover their ability to move an…

This study aims to translate and culturally adapt the Groningen Frailty Indicator (GFI) questionnaire for Greek patients with hip fractures. Researchers will enroll 89 adults over 65 who are undergoing hip fracture surgery. The goal is to create a reliable Greek version of the GF…

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study tests a simple conversation aid and brief training for doctors to improve discussions about anesthesia options with patients who need hip fracture surgery. About 1,881 adults aged 50 and older at six U.S. hospitals will take part. The goal is to see if this approach in…

This study looks at different ways to surgically fix a broken hip in adults under 65. The main goal is to see if a new implant keeps the bone more stable during healing compared to standard screws. Researchers will use a special X-ray method to measure any movement in the fractur…

This study looks at whether spinal anesthesia or general anesthesia leads to fewer lung complications after delayed hip fracture surgery in people aged 65 and older. Forty participants will be assigned to one of the two anesthesia types, and their lung function will be measured a…