Could a wearable ultrasound device ease knee arthritis pain without pills?

NCT ID NCT06257537

Completed Symptom relief Sponsor: ZetrOZ, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time

Summary

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pain will use the device at home over 24 weeks. The goal is to see if this long-duration ultrasound treatment can provide lasting pain relief and better joint mobility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Sustained acoustic medicine device with 2.5% diclofenac patch
What this could lead to: If it works, this could offer a non-invasive, drug-free option for managing knee osteoarthritis pain and improving mobility without surgery or daily pills.
What could go wrong: This is a Phase 2 trial, so results are still early. The device may not provide significant pain relief, and some people may experience skin irritation from the patch or discomfort from the ultrasound.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS OSTEO ARTHRITIS KNEE

Contacts and locations

Locations

Cayuga Medical Center - Medical Pain Consultants

Dryden, New York, 13053, United States
Orthopaedic Foundation

Stamford, Connecticut, 06905, United States
ZetrOZ Systems

Trumbull, Connecticut, 06611, United States

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