Could a wearable ultrasound device ease knee arthritis pain without pills?
NCT ID NCT06257537
First seen Jun 30, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pain will use the device at home over 24 weeks. The goal is to see if this long-duration ultrasound treatment can provide lasting pain relief and better joint mobility.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Sustained acoustic medicine device with 2.5% diclofenac patch
What this could lead to
If it works, this could offer a non-invasive, drug-free option for managing knee osteoarthritis pain and improving mobility without surgery or daily pills.
What could go wrong
This is a Phase 2 trial, so results are still early. The device may not provide significant pain relief, and some people may experience skin irritation from the patch or discomfort from the ultrasound.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cayuga Medical Center - Medical Pain Consultants
Dryden, New York, 13053, United States
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Orthopaedic Foundation
Stamford, Connecticut, 06905, United States
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ZetrOZ Systems
Trumbull, Connecticut, 06611, United States