Can sound waves soothe aching knees?

NCT ID NCT07738692

Completed Symptom relief Sponsor: Horus University Source: ClinicalTrials.gov ↗

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether different types of ultrasound therapy can ease pain and stiffness in people with knee osteoarthritis. Adults aged 45 to 65 with mild-to-moderate knee arthritis will receive ultrasound treatment, sometimes with a metformin gel applied to the skin. The study measures changes in pain, joint function, and range of motion to see if this approach offers relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ultrasound therapy (with or without metformin gel as a coupling medium)
What this could lead to: If effective, this could offer a non-invasive way to reduce knee pain and improve mobility in people with osteoarthritis.
What could go wrong: The trial is small and early, so results may not apply broadly. Ultrasound therapy may provide only temporary relief, and the addition of metformin gel is experimental.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE ARTHRITIS OSTEOARTHRITIS

Contacts and locations

Locations

Horus University

Quweisna, Monufia Governorate, 16916, Egypt

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