Can a Nerve-Freezing procedure transform knee replacement recovery?
NCT ID NCT06651762
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial tests whether cooling and ablating genicular nerves before total knee replacement surgery can reduce post-operative pain and improve recovery. Participants will receive either unilateral or bilateral genicular nerve cooled radiofrequency ablation, followed by epidural anesthesia and analgesia during and after surgery. The study measures pain control, functional outcomes, and knee range of motion to see if this approach enhances the multimodal pain management plan.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Cooled radiofrequency ablation of genicular nerves (a procedure performed before knee replacement surgery)
- What this could lead to
- If effective, this procedure could reduce post-surgical pain, improve recovery, and shorten hospital stays for people undergoing total knee replacement.
- What could go wrong
- This is a small, early-stage trial, and results may not apply to everyone. The procedure carries risks such as nerve damage or infection, and it may not provide significant pain relief.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
faculty of medicine Ain Shams University
Cairo, 02, Egypt
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