Drug cocktail aims to tame advanced leukemia
NCT ID NCT03895671
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether combining two drugs, ponatinib and 5-azacitidine, can improve survival in people with advanced chronic myeloid leukemia (CML). The study includes adults whose CML has progressed to an accelerated phase or a more aggressive blast crisis. Participants receive both drugs, and researchers track overall survival, safety, and how well the disease responds.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ponatinib and 5-azacitidine
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced chronic myeloid leukemia, potentially improving survival and disease control.
- What could go wrong
- This is an early-phase trial with a small number of participants. The combination may cause side effects, and it is not yet known if it will be more effective than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Centre Henri Becquerel
Rouen, France
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Centre Hospitalier Annecy Genevois
Pringy, France
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Centre Hospitalier D'Avignon
Avignon, France
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Centre Hospitalier Metropole Savoie
Chambéry, France
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Centre Hospitalier Regional Universitaire de Lille
Lille, France
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Centre Hospitalier Universitaire D'Amiens
Amiens, France
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Centre Hospitalier Universitaire de Clermont Ferrand
Clermont-Ferrand, France
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Centre Hospitalier Universitaire de Dijon
Dijon, France
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Centre Hospitalier Universitaire de Grenoble
Grenoble, France
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Centre Hospitalier Universitaire de Limoges
Limoges, France
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Centre Hospitalier Universitaire de Nantes
Nantes, France
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Centre Hospitalier Universitaire de Rennes
Rennes, France
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Centre Hospitalier de Caen-Normandie
Caen, France
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Centre Hospitalier de La Cote Basque
Bayonne, France
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Centre Hospitalier de Perpignan
Perpignan, France
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Centre Hospitalier de Strasbourg
Strasbourg, France
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Centre Hospitalier de Versailles
Versailles, France
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Centre Leon Berard
Lyon, France
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Chru de Nancy
Vandœuvre-lès-Nancy, France
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Hopital Avicenne
Bobigny, France
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Hopital Bicetre
Le Kremlin-Bicêtre, France
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Hopital Henri Mondor
Créteil, France
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Hopital Pitie-Salpetriere
Paris, France
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Hopital St Antoine
Paris, France
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Hopital St Louis
Paris, France
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Hospices Civils de Lyon
Pierre-Bénite, France
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Institut Bergonie
Bordeaux, France
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Institut Universitaire Du Cancer Toulouse
Toulouse, France
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Intitut Gustave Roussy
Villejuif, France