Can garlic and enzymes make menopause hormones safer?

NCT ID NCT02618148

Completed Disease control Sponsor: Trieu, Nguyen Thi, M.D. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding natural ingredients like garlic oil and nattokinase to standard hormone replacement therapy (HRT) could reduce the risk of blood clots in menopausal women. The trial involved 60 women divided into premenopausal and postmenopausal groups. Researchers measured how quickly estrogen levels rose to see if the combo was safer than HRT alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hormone replacement therapy (estradiol and progesterone) combined with garlic oil and nattokinase
What this could lead to: If successful, this could point toward a safer way to use hormone therapy for menopause symptoms by lowering the risk of blood clots.
What could go wrong: This is a small, early-phase study with only 60 participants, so results may not apply to everyone. The combination's safety and effectiveness need much larger trials to confirm.

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Conditions

The condition(s) this trial relates to.

osteoporosis prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENOPAUSE

Contacts and locations

Locations

Saigon Biopharma Company Limited

Ho Chi Minh City, 700000, Vietnam

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