Could less be more? testing whether kids can ease off arthritis meds
NCT ID NCT04891640
First seen Aug 05, 2026 · Last updated Aug 06, 2026 · Updated 1 time
Summary
This trial looks at whether children with juvenile spondyloarthritis who have stable, inactive disease can safely reduce or stop their TNFi medication without causing a flare. Participants are randomly assigned to continue their usual TNFi dose, take it less frequently, or stop it entirely. The study tracks how often disease flares occur and how children feel about their treatment, aiming to find the best strategy for managing long-term care.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tumor necrosis factor inhibitor (TNFi) medications, including adalimumab, certolizumab, etanercept, golimumab, and infliximab
- What this could lead to
- If successful, this could help doctors find the safest way to reduce or stop TNFi medications in children with stable juvenile spondyloarthritis, potentially lowering drug exposure and side effects while maintaining disease control.
- What could go wrong
- This is a pragmatic trial in routine care, so results may vary across clinics. Stopping or spacing out TNFi could increase the risk of disease flares, and the study's findings may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Akron Children's Hospital
Akron, Ohio, 44302, United States
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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Children's Healthcare of Atlanta
Atlanta, Georgia, 30329, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Colorado
Aurora, Colorado, 80045, United States
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Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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Children's National Health System
Washington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cohen Children's Medical Center
Queens, New York, 11040, United States
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Hospital for Special Surgery
New York, New York, 10021, United States
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Nemours Children's Health
Orlando, Florida, 32827, United States
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Nemours Children's Hospital
Wilmington, Delaware, 19803, United States
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Phoenix Children's
Phoenix, Arizona, 85006, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Randall Children's Hospital at Legacy Emanuel
Portland, Oregon, 97227, United States
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Riley Hospital for Children at IU Health
Indianapolis, Indiana, 46202, United States
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Seattle Children's Hospital
Seattle, Washington, 98105, United States
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St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Stanford University
Palo Alto, California, 94304, United States
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Texas Children's Hospital - Baylor College of Medicine
Houston, Texas, 77030, United States
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The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1E8, Canada
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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University of Iowa Stead Family Children's Hospital
Iowa City, Iowa, 52242, United States
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University of Michigan
Ann Arbor, Michigan, 48109, United States
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University of Minnesota Masonic Children's Hospital
Minneapolis, Minnesota, 55455, United States
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Vanderbilt Children's Hospital
Nashville, Tennessee, 37232, United States