Resveratrol plus diet shows promise for knee OA in obese postmenopausal women

NCT ID NCT07634302

Completed Symptom relief Sponsor: Federal State Budgetary Scientific Institution Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, function, and markers of joint health and inflammation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: resveratrol (a dietary supplement from Japanese knotweed)
What this could lead to: If it works, this could point toward a simple, natural supplement to boost the benefits of weight loss for knee pain and joint health in older women.
What could go wrong: This was a very short, small trial (10 days, 97 women). The results may not apply to men, longer treatment, or other populations. Resveratrol can cause mild digestive upset.

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Conditions

The condition(s) this trial relates to.

Inflammation Obesity obesity disorder osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

KNEE OSTEOARTHRITIS (KNEE OA) OBESITY (DISORDER)

Contacts and locations

Locations

Department of Cardiovascular Pathology and Diet Therapy

Moscow, 115446, Russia

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