OBESITY (DISORDER)

This study is investigating how the weight-loss medication tirzepatide affects muscle health in women with obesity. Researchers will give either the medication or a placebo to 30 premenopausal women for 24 weeks and measure changes in body weight, muscle strength, and muscle tiss…

This study aims to understand how two different weight loss medications affect bone health and body composition in adults with severe obesity. Researchers will follow 72 participants for six months, comparing the effects of tirzepatide (like Mounjaro/Zepbound) and liraglutide (li…

This study is testing whether a new, less invasive surgery using magnets to reroute the intestines works better than the medication semaglutide (like Ozempic) for controlling type 2 diabetes and weight in adults with obesity. It will enroll 20 adults with a BMI between 30-40 and …

This study is testing if a very low-calorie, ketogenic diet can help people with type 1 diabetes who are also obese lose weight safely. Fourteen adults will follow the strict diet for four weeks while using an automated insulin delivery system to closely manage their blood sugar.…

This study is testing whether adding a medication called semaglutide to a standard lifestyle program helps teens with obesity lose weight more effectively. Researchers want to see if the medication helps the body burn calories more efficiently during and after weight loss. The st…

This study aims to find the most effective way to give weekly feedback to people in a weight loss program. Researchers will enroll 300 adults with overweight or obesity and provide them with education and tools to track their diet, activity, and weight. Each week, participants wi…

This large study is observing how well combining traditional Chinese medicine with standard Western treatments works for people with obesity. Researchers will follow 10,000 adults to see which approaches help them lose weight and improve their health. The goal is to gather real-w…

This study is testing if adding a GLP-1 agonist medication (a type of drug used for weight loss) to standard diet and exercise advice can help regulate reproductive hormones in teenage girls who have both obesity and Polycystic Ovary Syndrome (PCOS). Researchers will enroll up to…

This study is testing whether regular far infrared sauna use can improve heart and metabolic health in adults with obesity. Researchers will measure changes in blood pressure, blood sugar, and artery stiffness in 20 participants after 30 sauna sessions. The goal is to see if this…

This study is following up with people who previously tried a special 5-day 'fasting-mimicking' diet (FMD) to see if continuing the diet every three months helps them keep the weight off and maintain improvements in heart health markers for a full year. It involves about 135 adul…

This study is looking for the best way for people to stop taking the weight-loss medication semaglutide. Researchers want to know if slowly reducing the dose helps people maintain their weight loss and health benefits better than stopping the medication all at once. They will com…

This study aims to see if providing free healthy prepared meals and nutrition education improves people's diets more than just getting exercise coaching. It involves 120 adults from Anson County, NC, who have or are at risk for chronic conditions like diabetes or heart disease. P…

This study aims to find the best way to predict if placing a breathing tube will be difficult for obese patients undergoing weight-loss surgery. Researchers will compare a standard checklist (the El Ganzouri Risk Index) with neck ultrasound measurements taken before surgery. The …

This study aims to understand how people's eating habits and diet quality change when they start taking GLP-1 medications for weight loss or diabetes. Researchers will follow 50 adults who are about to begin these medications, tracking what they eat and how they feel about their …

This small pilot study aims to see if a common food preservative (potassium sorbate) influences how much food people eat in a 24-hour period. Researchers will recruit 20 adults with obesity to test if it's feasible to measure food intake after a single dose of the additive versus…

This study is investigating whether bariatric (weight loss) surgery can improve cognitive functions like memory and attention in people with severe obesity. Researchers will follow 42 patients, testing their thinking skills using both traditional paper tests and a virtual reality…