OBESITY (DISORDER)

This study tests whether 30 sessions of far infrared sauna bathing can improve blood pressure and blood sugar control in adults with obesity. Researchers will measure changes in blood pressure, glucose levels, and artery stiffness. The study enrolls 20 people with a BMI between 3…

This study tests whether a very low-calorie ketogenic diet (600-800 calories per day) can help 14 adults with type 1 diabetes and obesity lose weight safely while using an automated insulin pump. Participants follow a structured 4-week meal replacement program under close medical…

This study looks at how the body adapts to weight loss in teens with obesity. It compares a lifestyle program alone to the same program plus a medication called semaglutide. The goal is to see which approach works better for long-term weight management. About 74 teens aged 12-17 …

This study looks at whether giving people healthy prepared meals and education helps them eat better compared to just getting physical activity coaching. About 120 adults in Anson County who have or are at risk for chronic diseases like obesity, diabetes, or heart disease will ta…

This study compares a new magnetic procedure to the medication semaglutide for controlling obesity and type 2 diabetes. About 20 adults with a BMI between 30 and 40 and type 2 diabetes will be randomly assigned to either the magnetic surgery or the drug. The goal is to see which …

This study aims to see how well a mix of traditional Chinese medicine and Western medicine works for people with obesity. Researchers will track at least 10,000 adults with a BMI of 28 or higher over 24 weeks, measuring weight loss and other health changes. The goal is to find be…

This study looks at whether a GLP-1 medication (a type of drug used for weight loss and diabetes) can improve the brain's control of reproductive hormones in obese teenage girls with PCOS. About 20 girls aged 12–18 will take the drug for 16 weeks while also getting diet and exerc…

This study is testing different ways to give weekly feedback to help people lose weight. Researchers want to see which type of message helps participants stay on track with their goals. About 300 adults with a BMI of 25 or higher will take part. The study uses a smartphone app an…

This study looks at 52 adults having weight-loss surgery to see which method better predicts a difficult breathing tube placement: a standard checklist or an ultrasound. Participants get both checks before surgery, and doctors record how the tube goes in. The goal is to find a mo…

This study looks at how adults taking GLP-1 medications (like Wegovy or Ozempic) change their eating habits. Researchers want to know if people eat healthier and what kind of nutrition support they need. About 50 adults who are about to start GLP-1 therapy for obesity or type 2 d…

This study looks at how compounds from mangoes (gallotannins) and a probiotic called Lactiplantibacillus pentosus affect gut bacteria and inflammation in people with obesity. Researchers will use stool samples from 20 volunteers (lean and obese) to test these effects in the lab. …

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 127 adults who are overweight or obese and will use a sma…

This study looks at whether a special diet that promotes a diverse gut microbiome can help people who have had bariatric surgery lose more weight and keep it off. Researchers will compare this diet to standard nutritional advice in 60 adults aged 25-65. The goal is to understand …

This study compares two weight-loss medications, tirzepatide and liraglutide, in 72 adults with severe obesity (BMI 40 or higher). Researchers will measure changes in bone health and body composition over 6 months. The goal is to understand if these drugs affect bone differently …

This pilot study explores whether a common food additive (potassium sorbate) affects how much people eat. Twenty adults with obesity will receive either the additive or a placebo, and their food intake over 24 hours will be measured. The goal is to see if this type of study is fe…

This study will test if weight-loss surgery can improve thinking skills like memory and attention. Researchers will use a virtual reality game and paper tests to measure brain function in 42 adults with severe obesity before and after surgery. The goal is to see if losing weight …

This study looks at how obesity damages blood vessels and how weight loss from bariatric surgery might reverse that damage. Researchers will track 85 adults with obesity before and after surgery, measuring blood vessel function and fat tissue changes. The goal is to understand if…

This study follows adults aged 30-65 who previously lost weight on a fasting-mimicking diet (FMD) or FMD plus a longevity diet. Researchers want to see if participants can keep off at least half of the fat they lost and maintain heart health improvements by doing the FMD every th…

This study looks at what happens when people stop taking the weight-loss drug semaglutide. It compares two ways of stopping: gradually reducing the dose versus stopping all at once. The goal is to see which approach helps people maintain their weight loss and keep their heart hea…

This study looks at how different exercise routines—moderate, vigorous, or short and intense—affect inflammation and the immune system in overweight but otherwise healthy adults. Researchers want to see if exercise can help reduce chronic low-grade inflammation, which is linked t…

This study looks at how tirzepatide, a weight-loss drug, affects the muscles of women with obesity. Thirty premenopausal women will receive either the drug or a placebo for 24 weeks. Researchers will measure muscle strength, size, and quality using scans and small tissue samples.…

This study looks at why people with obesity often have low iron levels. Researchers will test if losing weight (which reduces inflammation) or breathing low-oxygen air at night (which signals the body to make more red blood cells) can improve how well the body absorbs iron from f…

This study aims to understand how obesity leads to a type of heart failure called HFpEF, where the heart becomes stiff. Researchers will enroll 250 people with obesity and use heart ultrasounds, blood tests, and fat tissue samples to look for early signs of heart problems. Partic…