OBESITY (DISORDER)

This study tests whether tirzepatide, a drug used for diabetes and weight loss, is practical and acceptable for postmenopausal women who have had hormone receptor-positive breast cancer and are obese. Thirty participants will take the drug weekly for 24 weeks, with monthly check-…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This study tests whether a special diet that promotes a diverse gut microbiome can help people lose more weight and keep it off after bariatric surgery. Sixty adults aged 25-65 who are scheduled for weight-loss surgery will be randomly assigned to receive either standard nutritio…

This study tests whether 30 sessions of far infrared sauna bathing can improve blood pressure and blood sugar in adults with obesity. Twenty participants with a BMI between 30 and 45 will be enrolled. The goal is to see if regular heat therapy can help control these key health ma…

This study looks at what happens when people stop taking the weight-loss drug semaglutide. Researchers want to see if slowly reducing the dose over 16 weeks helps maintain weight loss and heart health better than stopping all at once. The study involves 98 adults with obesity who…

This study looks at whether tirzepatide, a drug used for weight loss, affects muscle function and structure in women with obesity. Thirty premenopausal women will receive either tirzepatide or a placebo for 24 weeks. Researchers will measure changes in body composition, muscle st…

This study looks at whether adding the drug semaglutide (Wegovy®) to a behavioral lifestyle program helps teenagers with obesity lose weight and adapt their metabolism. About 74 teens aged 12-17 will be split into two groups: one gets the lifestyle program alone for 6 months, the…

This study follows adults aged 30-65 who previously tried a fasting-mimicking diet (FMD) to see if they can maintain fat loss and heart health improvements for one more year. Participants will continue FMD cycles every three months. The goal is to check if these benefits last and…

This study tests whether providing healthy frozen meals, produce boxes, and nutrition counseling helps adults in Anson County eat better compared to those who only get physical activity coaching. About 120 participants with or at risk for chronic diseases like obesity, diabetes, …

This study tests whether a very low-calorie ketogenic diet (600-800 calories per day) can help people with type 1 diabetes and obesity lose weight safely. Fourteen adults will follow the diet for 4 weeks while using an automated insulin pump. The main goal is to see how much weig…

This study tests whether a weekly injection of semaglutide (a GLP-1 drug used for obesity) can improve the brain's reproductive hormone signals in obese adolescent girls with polycystic ovary syndrome (PCOS). Twenty girls aged 12–18 will receive the drug plus lifestyle advice for…

This study tests different types of weekly feedback to help people lose weight. 300 adults with overweight or obesity will receive feedback on their calorie intake, diet quality, or physical activity. The goal is to find which feedback works best for improving weight loss.

This study tests two ways of giving feedback to people in a weight loss program: one that only praises progress, and another that mixes praise with tips for improvement. Researchers want to see which style helps people lose more weight. About 127 adults with overweight or obesity…

This study looks at whether a program to reduce sitting time and increase light activity before bariatric surgery helps women with obesity achieve better weight loss and health. Seventy-two women scheduled for surgery will be guided to replace sedentary behavior with movement. Re…

This study looks at whether a person's genetic makeup can predict how much weight they will lose on the drugs semaglutide or tirzepatide. Researchers will follow 220 adults with obesity who are starting one of these medications for six months. By analyzing genetic risk scores and…

This study is tracking 10,000 adults with obesity to see how well integrated traditional Chinese medicine and Western medicine work in real-world settings. Researchers will collect health records, lab results, and lifestyle data to compare different treatment approaches. The goal…

This study looks at how obesity affects the heart and blood vessels, and how these change after bariatric surgery. Researchers will collect blood, urine, stool, and fat tissue samples from 85 adults before and after surgery. They aim to understand how fat tissue and gut bacteria …

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at whether losing weight and breathing low-oxygen air (like at high altitude) can help people with obesity absorb more iron. Iron deficiency is common in obesity, possibly due to inflammation. The study will measure iron absorption before and after a 6-week progr…

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This study will compare two methods—the El Ganzouri Risk Index and airway ultrasound—to predict difficult intubation in 52 adults undergoing bariatric surgery. Researchers will measure how well each method identifies patients who may have trouble with breathing tube placement. Th…

This pilot study tests whether a single dose of potassium sorbate, a common food preservative, changes how much people with obesity eat over 24 hours. Twenty adults will receive either the preservative or a placebo, then switch after a break. The main goal is to see if the study …

This study follows 50 adults who are about to start GLP-1 therapy for obesity or type 2 diabetes. Researchers will track how their eating habits change over 12 weeks using diet quality scores and body weight. The goal is to understand what dietary support people need while on the…

This study looks at how two weight-loss medications, tirzepatide and liraglutide, affect bone health and body composition in adults with severe obesity (BMI 40 or higher). Over 6 months, researchers will measure changes in bone turnover markers, weight, and body fat. The goal is …

This study will test if weight-loss surgery can improve thinking skills like memory and attention. Researchers will use a virtual reality game and standard tests to measure brain function in 42 adults with severe obesity before and after surgery. The goal is to see if losing weig…