New antibody aims to calm ankylosing spondylitis

NCT ID NCT06250062

Completed Disease control Sponsor: Shanghai Junshi Bioscience Co., Ltd. Source: ClinicalTrials.gov ↗

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This phase 2 trial tests an experimental drug called JS005 in adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. JS005 is a lab-made antibody that blocks IL-17A, a protein involved in inflammation. The study compares JS005 injections to a placebo to see if it reduces symptoms like back pain and stiffness over 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an experimental anti-IL-17A antibody called JS005
What this could lead to: If successful, JS005 could offer a new treatment option for people with active ankylosing spondylitis, reducing pain and stiffness.
What could go wrong: This is an early phase 2 trial, so results may not confirm effectiveness. Side effects from blocking IL-17A, such as infections, are possible.

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANKYLOSING SPONDYLITIS

Contacts and locations

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Locations

Beijing Chao-yang Hospital,Capital Medical University

Beijing, Beijing Municipality, 100020, China
Bethune First Hospital Of Jilin University

Changchun, Jilin, 130021, China
Binzhou Medical University Hospital

Binzhou, Shandong, 256603, China
Dongguan People's Hospital

Dongguan, Guangdong, 523018, China
First Affiliated Hospital of Gannan Medical University

Ganzhou, Jiangxi, 341000, China
Gansu Provincial Hospital

Lanzhou, Gansu, 730000, China
Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510180, China
Huizhou Central People's Hospital

Huizhou, Guangdong, 516001, China
Jieyang People's Hospital

Jieyang, Guangdong, 522000, China
Jilin Province People's Hospital

Jilin City, Changchun, 130021, China
Nanjing Drum Tower Hospital

Nanjing, Jiangsu, 210008, China
Nanyang Central Hospital

Nanyang, Henan, 473003, China
Pingxiang People's Hospital

Pingxiang, Jiangxi, 337055, China
Second Hospital of Shanxi Medical University

Taiyuan, Shanxi, 030001, China
Shandong Provincial Hospital

Jinan, Shandong, 250021, China
Shanghai Changzheng Hospital

Shanghai, Shanghai Municipality, 200003, China
Shenzhen People's Hospital

Shenzhen, Guangdong, 518020, China
Shenzhen Second People's Hospital

Shenzhen, Guangdong, 518035, China
Sun Yat-sen Memorial Hospital

Guangzhou, Guangdong, 510120, China
The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, 010030, China
The First Affiliated Hospital of Baotou Medical University

Baotou, Inner Mongolia, 014010, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Shantou University Medical College

Shantou, Guangdong, 515041, China
The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, 325000, China
The First Affiliated Hospital of Xiamen University

Xiamen, Fujian, China
The First Hospital of China Medical University

Shenyang, Liaoning, 110001, China
The First People's Hospital of Jiujiang City

Jiujiang, Jiangxi, 332000, China
The Second Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510630, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan, Hubei, 430022, China
West China Hospital of Sichuan University

Chengdu, Sichuan, 610041, China
Xinjiang Uygur Autonomous Region People's Hospital

Ürümqi, Xinjiang, 830001, China
Xuzhou Central Hospital

Xuzhou, Jiangsu, 221006, China
Zaozhuang Municipal Hospital

Zaozhuang, Shandong, 277100, China
Zhengzhou Central Hospital

Zhengzhou, Henan, 450001, China
Zhongshan Hospital Xiamen University

Xiamen, Fujian, 361004, China
Zhujiang Hospital of Southren Medical University

Guangzhou, Guangdong, 510280, China
Zhuzhou Central Hospital

Zhuzhou, Hunan, 412007, China

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