Scientists hunt for hidden DNA clues behind missing limbs

This study investigates whether changes in DNA methylation—a kind of chemical switch—might cause certain rare limb malformations that appear without a family history. Researchers will compare DNA samples from 40 people with Amelia (missing two or four limbs) or Femur Fibula Ulna Syndrome against matched controls. The goal is to identify regions where methylation differs, which could point to new causes for these conditions. No treatment or intervention is involved.