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Can a Platelet-Boosting drug speed recovery for older leukemia patients?

NCT ID NCT02071901

Completed Disease control Sponsor: Case Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This phase II trial investigates whether eltrombopag, a drug that stimulates platelet production, can help older adults with acute myeloid leukemia (AML) recover their platelet counts faster after initial chemotherapy. Older patients often experience slow platelet recovery, which raises the risk of bleeding and can delay necessary follow-up treatments. The study enrolls adults aged 60 and older with AML who are receiving standard induction chemotherapy, and measures how many achieve a safe platelet level and how quickly.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
eltrombopag olamine, a drug that stimulates platelet production
What this could lead to
If successful, this approach could help older AML patients recover platelets faster after chemotherapy, reducing bleeding risks and allowing timely follow-up treatment.
What could go wrong
This is a small, early-phase study without a placebo group, so results may not be definitive. Eltrombopag may also carry risks like liver problems or blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute basophilic leukemia acute erythroid leukemia acute megakaryoblastic leukemia acute megakaryoblastic leukemia in adult acute monocytic leukemia acute myeloblastic leukemia with maturation acute myeloblastic leukemia without maturation acute myeloid leukemia acute myeloid leukemia with 11q23 abnormalities acute myeloid leukemia with minimal differentiation acute myeloid leukemia with multilineage dysplasia acute myeloid leukemia with t(8;21)(q22;q22) translocation acute myeloid leukemia, del(5q31-q32) acute myeloid leukemia, inv(16)(p13.1;q22) acute myeloid leukemia, t(16;16)(p13.1;q22) acute myelomonocytic leukemia M4 adult acute monocytic leukemia Congenital Abnormalities Leukemia, Eosinophilic, Acute Leukemia, Myelomonocytic, Acute therapy related acute myeloid leukemia and myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA WITH MULTILINEAGE DYSPLASIA FOLLOWING MYELODYSPLASTIC SYNDROME ADULT ACUTE BASOPHILIC LEUKEMIA ADULT ACUTE EOSINOPHILIC LEUKEMIA ADULT ACUTE MEGAKARYOBLASTIC LEUKEMIA (M7) ADULT ACUTE MINIMALLY DIFFERENTIATED MYELOID LEUKEMIA (M0) ADULT ACUTE MONOBLASTIC LEUKEMIA (M5A) ADULT ACUTE MONOCYTIC LEUKEMIA (M5B) ADULT ACUTE MYELOBLASTIC LEUKEMIA WITH MATURATION (M2) ADULT ACUTE MYELOBLASTIC LEUKEMIA WITHOUT MATURATION (M1) ADULT ACUTE MYELOID LEUKEMIA IN REMISSION ADULT ACUTE MYELOID LEUKEMIA WITH 11Q23 (MLL) ABNORMALITIES ADULT ACUTE MYELOID LEUKEMIA WITH DEL(5Q) ADULT ACUTE MYELOID LEUKEMIA WITH INV(16)(P13;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(16;16)(P13;Q22) ADULT ACUTE MYELOID LEUKEMIA WITH T(8;21)(Q22;Q22) ADULT ACUTE MYELOMONOCYTIC LEUKEMIA (M4) ADULT ERYTHROLEUKEMIA (M6A) ADULT PURE ERYTHROID LEUKEMIA (M6B) SECONDARY ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

  • Case Comprehensive Cancer Center

    Cleveland, Ohio, 44106-5065, United States

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