Precision radiation may boost stem cell transplant success in tough leukemias
NCT ID NCT02094794
First seen Jul 01, 2026 · Last updated Jul 02, 2026 · Updated 1 time
Summary
This study tests a precise radiation method called total marrow and lymphoid irradiation (TMLI) given with two chemotherapy drugs (etoposide and cyclophosphamide) before a donor stem cell transplant. The goal is to safely deliver higher radiation doses to the bone marrow to wipe out cancer cells while protecting nearby organs. The trial enrolls adults with high-risk acute lymphocytic or myeloid leukemia that has not responded to previous treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- total marrow and lymphoid irradiation (TMLI), cyclophosphamide, etoposide
- What this could lead to
- If successful, this approach could improve outcomes for patients with hard-to-treat leukemia by delivering higher radiation doses to the bone marrow while reducing side effects.
- What could go wrong
- This is a phase 2 trial, so results are still preliminary. The combination may still cause serious side effects, and it is not yet proven to be better than standard treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ACUTE LYMPHOBLASTIC LEUKEMIA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
Duarte, California, 91010, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Low-Dose antifungal shield vulnerable patients from deadly fungal infections?
- Can a gentler chemo prep make stem cell transplants safer for blood cancer patients?
- A simple blood test may reveal hidden infertility risk in young cancer survivors
- Can donor immune cells tame stem cell transplant risks?
- A simple blood draw could spare kids with leukemia from painful bone marrow tests
- Can a smart drug missile tame Hard-to-Treat leukemia?