Radioactive antibody hones in on cancer cells to boost transplant success
NCT ID NCT05139004
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This trial tests whether adding a radioactive antibody (90Y-DOTA-anti-CD25 basiliximab) to standard chemotherapy and targeted radiation can better prepare the bone marrow for a stem cell transplant in people with high-risk acute leukemia or myelodysplastic syndrome. The antibody seeks out and destroys cancer cells carrying the CD25 marker, while the chemo and radiation clear space for donor cells. The goal is to find the safest dose and see if this combination improves transplant outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- 90Y-DOTA-anti-CD25 basiliximab (radioactive antibody)
- What this could lead to
- If it works, this approach could improve the success of stem cell transplants for people with hard-to-treat leukemia or MDS.
- What could go wrong
- This is an early-phase trial with only 7 participants, so the dose and safety are still being figured out. Radioactive and chemotherapy drugs can cause serious side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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City of Hope Medical Center
Duarte, California, 91010, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a Two-Drug combo outsmart a deadly leukemia?
- Can a new pill take on Hard-to-Treat leukemia?
- Can pressurized oxygen boost cord blood transplants?