Can a drug that calms inflammation ease chronic sinusitis?

NCT ID NCT04678856

Completed Disease control Sponsor: Sanofi Source: ClinicalTrials.gov ↗

First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This trial tests whether dupilumab, an injectable drug that blocks certain inflammatory signals, can reduce sinus swelling and improve symptoms like loss of smell and runny nose in adults with chronic sinusitis who do not have nasal polyps. Participants receive either dupilumab or a placebo for 24 weeks. The study measures changes in CT scans and symptom scores to see if the drug offers relief for this hard-to-treat condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: an injectable drug called dupilumab
What this could lead to: If it works, this could offer a new treatment option for people with chronic sinusitis who don't have nasal polyps and haven't been helped by standard therapies.
What could go wrong: This is a small, early-phase trial, so results may not apply to everyone. Dupilumab can cause injection-site reactions and allergic reactions, and it may not improve symptoms for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis paranasal sinus disorder Respiration Disorders respiratory system disorder sinusitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITHOUT NASAL POLYPS CHRONIC SINUSITIS RESPIRATORY DISORDER SINUS DISORDER SINUSITIS

Contacts and locations

Locations

Alamo ENT Associates Site Number : 8400021

San Antonio, Texas, 78258, United States
Bensch Clinical Research LLC Site Number : 8400015

Stockton, California, 95207, United States
Colorado Allergy and Asthma Centers, PC Site Number : 8400003

Denver, Colorado, 80230, United States
Eastern Virginia Medical School (EVMS) Medical Group - Otola Site Number : 8400009

Norfolk, Virginia, 23507, United States
Essential Medical Research, LLC Site Number : 8400014

Tulsa, Oklahoma, 74137, United States
Investigational Site Number : 0320001

Ciudad Autonoma Buenos Aires, C1425BEN, Argentina
Investigational Site Number : 0320002

Buenos Aires, C1121ABE, Argentina
Investigational Site Number : 0320003

Ciudad Autonoma Buenos Aires, C1414AIF, Argentina
Investigational Site Number : 0560001

Leuven, 3000, Belgium
Investigational Site Number : 0560002

Ghent, 9000, Belgium
Investigational Site Number : 1240001

Montreal, Quebec, H2X 3E4, Canada
Investigational Site Number : 1240002

Trois-Rivières, Quebec, G8T 7A1, Canada
Investigational Site Number : 1240003

Québec, G1V 4W2, Canada
Investigational Site Number : 1240005

Québec, G1V 4G5, Canada
Investigational Site Number : 1240007

Kingston, Ontario, K7L 2V7, Canada
Investigational Site Number : 1240010

Hamilton, Ontario, L8L 2X2, Canada
Investigational Site Number : 1240012

Montreal, Quebec, H4A 3J1, Canada
Investigational Site Number : 1240013

Vancouver, British Columbia, V6Z 1Y6, Canada
Investigational Site Number : 1240016

London, Ontario, N6A 4V2, Canada
Investigational Site Number : 1520001

Santiago, Reg Metropolitana de Santiago, 8207257, Chile
Investigational Site Number : 1560001

Beijing, 100730, China
Investigational Site Number : 1560005

Changchun, 130021, China
Investigational Site Number : 1560006

Shanghai, 200065, China
Investigational Site Number : 1560008

Yantai, 264000, China
Investigational Site Number : 1560010

Chongqing, 400016, China
Investigational Site Number : 1560013

Changsha, 410013, China
Investigational Site Number : 3480001

Pécs, 7621, Hungary
Investigational Site Number : 3480004

Budapest, 1115, Hungary
Investigational Site Number : 4100002

Seoul, Seoul-teukbyeolsi, 135-710, South Korea
Investigational Site Number : 4100003

Seoul, Seoul-teukbyeolsi, 07061, South Korea
Investigational Site Number : 6200001

Guimarães, 4810-061, Portugal
Investigational Site Number : 6200002

Aveiro, 3810-501, Portugal
Investigational Site Number : 6200003

Matosinhos Municipality, 4464-513, Portugal
Investigational Site Number : 6430001

Stavropol, 355020, Russia
Investigational Site Number : 6430002

Saint Petersburg, 197022, Russia
Investigational Site Number : 6430003

Saint Petersburg, 197022, Russia
Investigational Site Number : 6430005

Moscow, 121359, Russia
Investigational Site Number : 7240001

Barcelona, Barcelona [Barcelona], 08036, Spain
Investigational Site Number : 7240002

Seville, Andalusia, 41009, Spain
Investigational Site Number : 7240004

Jerez de la Frontera, Cádiz, 11407, Spain
Investigational Site Number : 7240005

Madrid / Madrid, Madrid, Comunidad de, 28040, Spain
Investigational Site Number : 7240007

Santander, Cantabria, 39008, Spain
Investigational Site Number : 7240008

Pamplona, Navarre, 31008, Spain
Investigational Site Number : 7240009

Madrid, Madrid, Comunidad de, 28027, Spain
Investigational Site Number : 7240010

Madrid, 28034, Spain
Investigational Site Number : 7520001

Stockholm, 171 76, Sweden
Investigational Site Number : 8040001

Ivano-Frankivsk, 76018, Ukraine
Investigational Site Number : 8040002

Kyiv, 03680, Ukraine
Investigational Site Number : 8040004

Kharkiv, 61166, Ukraine
Investigational Site Number : 8040005

Dnipro, 49006, Ukraine
Investigational Site Number : 8040007

Kyiv, 04050, Ukraine
Investigational Site Number : 8040008

Kyiv, 01033, Ukraine
Nebraska Medical Research Institute Site Number : 8400007

Papillion, Nebraska, 68046, United States
Optimed Research, LTD Site Number : 8400017

Columbus, Ohio, 43235, United States
Pharmaceutical Research & Consulting, Inc. Site Number : 8400006

Dallas, Texas, 75231, United States
Sacramento Ear, Nose & Throat Site Number : 8400010

Roseville, California, 95661, United States
University of Missouri Health System Site Number : 8400016

Columbia, Missouri, 65212, United States
Vital Prospects Clinical Research Institute, P.C. Site Number : 8400004

Tulsa, Oklahoma, 74136, United States

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