Antibiotics vs. placebo for Kids' sinus infections: which works best?
NCT ID NCT07732699
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The goal is to see if antibiotics meaningfully improve recovery and whether factors like allergy or illness severity affect their effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- amoxicillin, amoxicillin-clavulanate, or placebo
- What this could lead to
- If antibiotics prove clearly better than placebo, this could confirm their value for childhood sinus infections and help doctors choose the right one.
- What could go wrong
- This is a Phase 4 trial, but antibiotics may not work for all children, and some may experience side effects like diarrhea. The placebo group helps clarify true benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
-
Duke University Hospital
Durham, North Carolina, 27705, United States
-
Seattle Children's Hospital
Seattle, Washington, 98105, United States
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
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University of Colorado, Denver
Denver, Colorado, 80204, United States
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