Triple-Action nasal spray could ease chronic sinusitis

NCT ID NCT07635433

Not yet recruiting Disease control Sponsor: The First Affiliated Hospital of Xinxiang Medical College Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a nasal spray for adults with chronic sinusitis (without polyps). The spray contains stem cell exosomes to heal the nose lining, an antibiotic to kill bacteria, and an enzyme to break up thick mucus. 108 participants will use the spray twice daily for 4 weeks to check safety and see if it improves symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A nasal spray containing stem cell exosomes, an antibiotic (mupirocin), and an enzyme (DNase I) in a gel that turns solid inside the nose
What this could lead to: If it works, this could offer a new non-surgical option for people with chronic sinusitis, reducing infections and improving quality of life.
What could go wrong: This is an early phase 1 trial with only 108 people, so safety and effectiveness are not yet proven. The spray may cause side effects like nose irritation or allergic reactions.

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Conditions

The condition(s) this trial relates to.

chronic rhinosinusitis staphylococcal infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

More trials for these conditions

Other studies related to the condition(s) this trial covers.