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Can a new drug shrink nasal polyps and restore smell?

NCT ID NCT05891483

Completed Disease control Sponsor: Guangdong Hengrui Pharmaceutical Co., Ltd Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether an experimental drug called SHR-1905 can reduce nasal polyps and improve symptoms like congestion and loss of smell in people with chronic sinusitis. Participants will receive either the drug or a placebo alongside their usual nasal spray treatment. The study aims to find a safe and effective dose for this condition.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
an experimental drug called SHR-1905
What this could lead to
If effective, SHR-1905 could offer a new treatment option for people with chronic sinusitis and nasal polyps who still have symptoms despite standard nasal sprays.
What could go wrong
This is an early phase 2 trial with only 114 participants, so results may not apply to everyone. The drug's safety and effectiveness are still unproven, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC RHINOSINUSITIS WITH NASAL POLYPS

Contacts and locations

Locations

  • Eye & Ent Hospital of Fudan University

    Shanghai, Shanghai Municipality, 200031, China

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